Palmitic and oleic acid: the yin and yang of fatty acids in type 2 diabetes mellitus

X Palomer, J Pizarro-Delgado, E Barroso… - Trends in Endocrinology …, 2018 - cell.com
Increased plasma non-esterified fatty acids (NEFAs) link obesity with insulin resistance and
type 2 diabetes mellitus (T2DM). However, in contrast to the saturated FA (SFA) palmitic …

Sphingolipids and phospholipids in insulin resistance and related metabolic disorders

PJ Meikle, SA Summers - Nature Reviews Endocrinology, 2017 - nature.com
Obesity, insulin resistance, type 2 diabetes mellitus and cardiovascular disease form a
metabolic disease continuum that has seen a dramatic increase in prevalence in developed …

Are we close to defining a metabolomic signature of human obesity? A systematic review of metabolomics studies

OD Rangel-Huerta, B Pastor-Villaescusa, A Gil - Metabolomics, 2019 - Springer
Introduction Obesity is a disorder characterized by a disproportionate increase in body
weight in relation to height, mainly due to the accumulation of fat, and is considered a …

Interorgan metabolic crosstalk in human insulin resistance

S Gancheva, T Jelenik… - Physiological …, 2018 - journals.physiology.org
Excessive energy intake and reduced energy expenditure drive the development of insulin
resistance and metabolic diseases such as obesity and type 2 diabetes mellitus. Metabolic …

[HTML][HTML] Therapeutic properties and use of extra virgin olive oil in clinical nutrition: a narrative review and literature update

A Jiménez-Sánchez, AJ Martínez-Ortega… - Nutrients, 2022 - mdpi.com
Extra virgin olive oil (EVOO) is a cornerstone of the Mediterranean diet (MedD). In this
narrative review, we synthesize and illustrate the various characteristics and clinical …

[HTML][HTML] Lipids in psychiatric disorders and preventive medicine

M Schneider, B Levant, M Reichel, E Gulbins… - Neuroscience & …, 2017 - Elsevier
Psychiatric disorders like mood disorders, schizophrenia, or drug addiction affect a sizeable
proportion of the human population and severely compromise quality of life. Therefore …

Potential impact and study considerations of metabolomics in cardiovascular health and disease: a scientific statement from the American Heart Association

S Cheng, SH Shah, EJ Corwin, O Fiehn… - Circulation …, 2017 - ahajournals.org
Through the measure of thousands of small-molecule metabolites in diverse biological
systems, metabolomics now offers the potential for new insights into the factors that …

Could ceramides become the new cholesterol?

SA Summers - Cell metabolism, 2018 - cell.com
The Mayo Clinic recently introduced a diagnostic test that quantifies plasma ceramides in
order to identify patients at risk of major adverse cardiac events. By comparing recent …

Mass spectrometry‐based lipidomics in food science and nutritional health: A comprehensive review

T Sun, X Wang, P Cong, J Xu… - … Reviews in Food Science …, 2020 - Wiley Online Library
With the advance in science and technology as well as the improvement of living standards,
the function of food is no longer just to meet the needs of survival. Food science and its …

Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism

Y Tang, M Wallace, J Sanchez-Gurmaches… - Nature …, 2016 - nature.com
Adipose tissue de novo lipogenesis (DNL) positively influences insulin sensitivity, is reduced
in obesity, and predicts insulin resistance. Therefore, elucidating mechanisms controlling …