[HTML][HTML] Flaxseed (Linum usitatissimum L.) bioactive compounds and peptide nomenclature: A review

YY Shim, B Gui, PG Arnison, Y Wang… - Trends in food science & …, 2014 - Elsevier
Highlights•Flax compounds; linatine, cyanogenic glycosides, Cd and mucilage are
discussed.•The difficulty in attributing bioactivity to flaxseed compounds is discussed.•A …

Health benefits of flaxseed and its peptides (linusorbs)

YY Shim, JH Kim, JY Cho… - Critical Reviews in Food …, 2024 - Taylor & Francis
Flaxseed (Linum usitatissimum L.) has been associated with numerous health benefits. The
flax plant synthesizes an array of biologically active compounds including peptides or …

[HTML][HTML] The synergistic treatment of cyclolinopeptide J and calcium carbonate nanoparticles for osteoporosis via BMP/Wnt signaling: in vivo and in vitro

J Chen, W Li, YY Lee, Z Cai, J Chen, Y Wang - Journal of Functional Foods, 2023 - Elsevier
This research focuses on the investigation of cyclolinopeptide J (CLJ), a bioactive peptide
naturally present in flaxseed, which loaded in porous calcium carbonate (CA) nanoparticles …

A two-step method of cyclolinopeptide (linusorb) preparation from flaxseed cake via dry-screening

Z Cai, C Xu, Z Song, N Zhang, J Zhao, YY Lee… - Food Chemistry, 2024 - Elsevier
Abstract Linusorbs (LO), cyclolinopeptides, are a group of cyclic hydrophobic peptides and
considered a valuable by-product of flaxseed oil due to numerous health benefits. Currently …

Non‐oxidized and oxidized flaxseed orbitides differently induce HepG2 cell apoptosis: involvement of cellular uptake and membrane death receptor DR4

C Peng, J Li, A Zhao, S Yu, L Zheng… - Journal of the Science …, 2024 - Wiley Online Library
BACKGROUND Flaxseed orbitides have health‐promoting properties, particularly potent
anti‐cancer activity. However, flaxseed orbitides containing a methionine structure, such as …

Activation spectra of human bitter taste receptors stimulated with cyclolinopeptides corresponding to fresh and aged linseed oil

T Lang, O Frank, R Lang, T Hofmann… - Journal of agricultural …, 2022 - ACS Publications
Linseed oil is rich in unsaturated fatty acids, and its increased consumption could aid in
health-promoting nutrition. However, rapid oxidation of linseed oil and concomitant …

Orbitides from flaxseed (Linum usitatissimum L.): A comprehensive review

YY Shim, Z Song, PD Jadhav, MJT Reaney - Trends in Food Science & …, 2019 - Elsevier
Abstract Background Bioactive orbitides (linusorbs, LOs) from flaxseed (Linum
usitatisssimum L.) contribute to the bitter flavor of flaxseed oil. Methods were developed for …

Plant protein flavor chemistry fundamentals and techniques to mitigate undesirable flavors

S Vatansever, B Chen, C Hall - Sustainable Food Proteins, 2024 - Wiley Online Library
Many plant protein ingredients have unpleasant flavor (eg, green, beany, bitterness)
characteristics. Isolation of the protein fraction will reduce the intensity of the undesirable …

Linoorbitides and enterolactone mitigate inflammation-induced oxidative stress and loss of intestinal epithelial barrier integrity

AA Almousa, F Meurens, ES Krol, J Alcorn - International …, 2018 - Elsevier
Barrier integrity dysfunction and oxidative stress are considered hallmarks of inflammatory
bowel disease (IBD) pathogenesis. Their mitigation continues to be a drug discovery target …

A practical and fast isolation of 12 cyclolinopeptides (linusorbs) from flaxseed oil via preparative HPLC with phenyl-hexyl column

X Liu, Z Cai, WJ Lee, X Lu, MJT Reaney, J Zhang, Y Li… - Food Chemistry, 2021 - Elsevier
Linusorbs, known as cyclolinopeptides, are a group of cyclic hydrophobic peptides derived
from flaxseed oil with various health benefits. However, the current research efforts on both …