Background The results of animal experiments show that quinolone antibacterial drugs may
permanently damage the soft tissues of the weight-bearing joints of young animals. Out of …

For several years, the scientific community has been concerned about the presence of
pharmaceuticals in the wild, since these compounds may have unpredictable deleterious …

The sensitivity of the immature skeletal system during postnatal mammalian development
was discussed during the workshop" Children as a Sensitive Subgroup and their Role in …

A study in young beagle dogs was performed in which the animals were treated for 2 weeks
with ciprofloxacin at oral doses of 0, 10, 30 or 90 mg/kg per day. Immediately after treatment …

Introduction: Ciprofloxacin is one of fluoroquinolone derivatives, which has a broad
spectrum bactericidal activity. It is contraindicated in children and adolescents because of its …

Objectives: Garenoxacin is a novel des-F (6)-quinolone with good anti-anaerobe activity.
The accumulation of garenoxacin and five other quinolones in the presence and absence of …

It is widely accepted that tendon and cartilage are adversely affected with the toxic effects of
quinolones. However, the effects of quinolones on synovium have not been deciphered …

Quinolones have been reported to induce adverse effects on articular cartilage, tendons and
ligaments. However, the effects of quinolones on menisci have not been revealed. The …

Background Fluoroquinolones are in wide clinical use as safe and effective antibiotics.
Articular cartilage, tendons, and epiphyseal growth plates have been recognized as targets …

Garenoxacin, a novel des-F (6)-quinolone, was tested against 40423 pathogenic isolates
associated with community-acquired respiratory tract infections (CA-RTIs). The strains …