Acetogenins as potential anticancer agents
M Mangal, M Imran Khan… - Anti-Cancer Agents in …, 2016 - ingentaconnect.com
Acetogenins (ACG) are naturally occurring compounds that are chemically one of the least
investigated families. In the review, we have provided a comprehensive listing of 133 of …
investigated families. In the review, we have provided a comprehensive listing of 133 of …
[PDF][PDF] Annonaceous acetogenins as a new anticancer agent
In spite of the many advances in modern scientific medicine, plant-based traditional
medicine still plays an important role in the health care. The acetogenins of Annonaceae are …
medicine still plays an important role in the health care. The acetogenins of Annonaceae are …
Thiophene-3-carboxamide analogue of annonaceous acetogenins as antitumor drug lead
N Kojima, T Fushimi, T Tatsukawa, T Tanaka… - European journal of …, 2014 - Elsevier
Five novel acetogenin analogues with a furan, thiophene, or thiazole ring were synthesized,
and their inhibitory activities toward human cancer cell lines were evaluated. The analogues …
and their inhibitory activities toward human cancer cell lines were evaluated. The analogues …
Structure–antitumor activity relationship of hybrid acetogenins focusing on connecting groups between heterocycles and the linker moiety
K Ohta, T Fushimi, M Okamura, A Akatsuka, S Dan… - RSC …, 2022 - pubs.rsc.org
We studied hybrid molecules of annonaceous acetogenins and mitochondrial complex I-
inhibiting insecticides to develop a novel anticancer agent. A structure–antitumor activity …
inhibiting insecticides to develop a novel anticancer agent. A structure–antitumor activity …
Theoretical and experimental studies of 1, 5, 7-triazabicyclo [4.4. 0] dec-5-ene-catalyzed ring opening/ring closure reaction mechanism for 5-, 6-and 7-membered …
I Nifant'ev, A Shlyakhtin, V Bagrov, B Lozhkin… - Reaction Kinetics …, 2016 - Springer
The ring-opening polymerizations (ROP) of five-, six-, and seven-membered ring cyclic
substrates, as well as the transesterification of acyclic esters, with 1, 5, 7-triazabicyclo [4.4. 0] …
substrates, as well as the transesterification of acyclic esters, with 1, 5, 7-triazabicyclo [4.4. 0] …
Fischer Reaction with 2‐Perfluoroalkylated Cyclic Imines―An Efficient Route to 2‐Perfluoroalkyl‐Substituted Tryptamines and Their Derivatives and Homologues
The reaction of 2‐perfluoroalkyl‐substituted cyclic imines with arylhydrazines was
investigated. We found that 2‐perfluoroalkylated cyclic imines are highly reactive …
investigated. We found that 2‐perfluoroalkylated cyclic imines are highly reactive …
[HTML][HTML] Hit-to-lead optimization of a latency-associated nuclear antigen inhibitor against Kaposi's sarcoma-associated herpesvirus infections
P Kirsch, SC Stein, A Berwanger, J Rinkes… - European Journal of …, 2020 - Elsevier
The Latency-associated nuclear antigen (LANA) plays a central role for the latent
persistence of the Kaposi's Sarcoma Herpesvirus (KSHV) in the human host and helps to …
persistence of the Kaposi's Sarcoma Herpesvirus (KSHV) in the human host and helps to …
Synthesis of Acetogenin Analogs Comprising Pyrimidine Moieties Linked by Amine Bonds and Their Inhibitory Activity against Human Cancer Cell Lines
H Hosomi, A Akatsuka, S Dan, H Iwasaki… - Chemical and …, 2022 - jstage.jst.go.jp
Here, we synthesized three acetogenin analogs containing pyrimidine moieties linked by
amine bonds, which represent the skeleton structure of pyrimidifen, a mitochondrial complex …
amine bonds, which represent the skeleton structure of pyrimidifen, a mitochondrial complex …
SARs of ACGs against diverse human tumor cells
Y Chen, Y Qiu, Y Miao, F Yuan, J Chen, X Li - Medicinal Chemistry …, 2015 - Springer
Abstract Four mono-tetrahydrofuran (THF), six adjacent bis-THF and six nonadjacent bis-
THF annonaceous acetogenins (ACGs) were selected for antitumor activity testing against …
THF annonaceous acetogenins (ACGs) were selected for antitumor activity testing against …
[PDF][PDF] Syntheses of a pyrrolidine analog of a tetrahydrofuran containing acetogenin, cis-solamin
K Ohnishi, H Sakurai, K Kobayashi… - …, 2015 - triggered.stanford.clockss.org
Practical synthesis of a pyrrolidine analog of a mono-THF acetogenin as a proto-type analog
to evaluate the effect of a heteroatom in the mono-THF ring of acetogenins was achieved …
to evaluate the effect of a heteroatom in the mono-THF ring of acetogenins was achieved …