Acetogenins as potential anticancer agents

M Mangal, M Imran Khan… - Anti-Cancer Agents in …, 2016 - ingentaconnect.com
Acetogenins (ACG) are naturally occurring compounds that are chemically one of the least
investigated families. In the review, we have provided a comprehensive listing of 133 of …

[PDF][PDF] Annonaceous acetogenins as a new anticancer agent

WS Qayed, AS Aboraia, HM Abdel-Rahman… - Der Pharma …, 2015 - academia.edu
In spite of the many advances in modern scientific medicine, plant-based traditional
medicine still plays an important role in the health care. The acetogenins of Annonaceae are …

Thiophene-3-carboxamide analogue of annonaceous acetogenins as antitumor drug lead

N Kojima, T Fushimi, T Tatsukawa, T Tanaka… - European journal of …, 2014 - Elsevier
Five novel acetogenin analogues with a furan, thiophene, or thiazole ring were synthesized,
and their inhibitory activities toward human cancer cell lines were evaluated. The analogues …

Structure–antitumor activity relationship of hybrid acetogenins focusing on connecting groups between heterocycles and the linker moiety

K Ohta, T Fushimi, M Okamura, A Akatsuka, S Dan… - RSC …, 2022 - pubs.rsc.org
We studied hybrid molecules of annonaceous acetogenins and mitochondrial complex I-
inhibiting insecticides to develop a novel anticancer agent. A structure–antitumor activity …

Theoretical and experimental studies of 1, 5, 7-triazabicyclo [4.4. 0] dec-5-ene-catalyzed ring opening/ring closure reaction mechanism for 5-, 6-and 7-membered …

I Nifant'ev, A Shlyakhtin, V Bagrov, B Lozhkin… - Reaction Kinetics …, 2016 - Springer
The ring-opening polymerizations (ROP) of five-, six-, and seven-membered ring cyclic
substrates, as well as the transesterification of acyclic esters, with 1, 5, 7-triazabicyclo [4.4. 0] …

Fischer Reaction with 2‐Perfluoroalkylated Cyclic Imines―An Efficient Route to 2‐Perfluoroalkyl‐Substituted Tryptamines and Their Derivatives and Homologues

OI Shmatova, NE Shevchenko… - European Journal of …, 2015 - Wiley Online Library
The reaction of 2‐perfluoroalkyl‐substituted cyclic imines with arylhydrazines was
investigated. We found that 2‐perfluoroalkylated cyclic imines are highly reactive …

[HTML][HTML] Hit-to-lead optimization of a latency-associated nuclear antigen inhibitor against Kaposi's sarcoma-associated herpesvirus infections

P Kirsch, SC Stein, A Berwanger, J Rinkes… - European Journal of …, 2020 - Elsevier
The Latency-associated nuclear antigen (LANA) plays a central role for the latent
persistence of the Kaposi's Sarcoma Herpesvirus (KSHV) in the human host and helps to …

Synthesis of Acetogenin Analogs Comprising Pyrimidine Moieties Linked by Amine Bonds and Their Inhibitory Activity against Human Cancer Cell Lines

H Hosomi, A Akatsuka, S Dan, H Iwasaki… - Chemical and …, 2022 - jstage.jst.go.jp
Here, we synthesized three acetogenin analogs containing pyrimidine moieties linked by
amine bonds, which represent the skeleton structure of pyrimidifen, a mitochondrial complex …

SARs of ACGs against diverse human tumor cells

Y Chen, Y Qiu, Y Miao, F Yuan, J Chen, X Li - Medicinal Chemistry …, 2015 - Springer
Abstract Four mono-tetrahydrofuran (THF), six adjacent bis-THF and six nonadjacent bis-
THF annonaceous acetogenins (ACGs) were selected for antitumor activity testing against …

[PDF][PDF] Syntheses of a pyrrolidine analog of a tetrahydrofuran containing acetogenin, cis-solamin

K Ohnishi, H Sakurai, K Kobayashi… - …, 2015 - triggered.stanford.clockss.org
Practical synthesis of a pyrrolidine analog of a mono-THF acetogenin as a proto-type analog
to evaluate the effect of a heteroatom in the mono-THF ring of acetogenins was achieved …