A forward vision for chemodynamic therapy: issues and opportunities

P Zhao, H Li, W Bu - Angewandte Chemie International Edition, 2023 - Wiley Online Library
Since the insight to fuse Fenton chemistry and nanomedicine into cancer therapy, great
signs of progress have been made in the field of chemodynamic therapy (CDT). However …

Organelle-specific regulation of ferroptosis

X Chen, R Kang, G Kroemer, D Tang - Cell Death & Differentiation, 2021 - nature.com
Ferroptosis, a cell death modality characterized by iron-dependent lipid peroxidation, is
involved in the development of multiple pathological conditions, including ischemic tissue …

Persister cancer cells: Iron addiction and vulnerability to ferroptosis

R Rodriguez, SL Schreiber, M Conrad - Molecular cell, 2022 - cell.com
Ferroptosis is a unique type of non-apoptotic cell death resulting from the unrestrained
occurrence of peroxidized phospholipids, which are subject to iron-mediated production of …

Targeting ferroptosis in acute kidney injury

L Ni, C Yuan, X Wu - Cell Death & Disease, 2022 - nature.com
Acute kidney injury (AKI) is a major public health problem with high incidence and mortality.
As a form of programmed cell death (PCD), ferroptosis could be considered as a process of …

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

L Galluzzi, I Vitale, SA Aaronson, JM Abrams… - Cell Death & …, 2018 - nature.com
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

[PDF][PDF] Photodynamic therapy in cancer treatment-an update review

AF dos Santos, DRQ de Almeida… - J. Cancer …, 2019 - pdfs.semanticscholar.org
Cancer remains a worldwide health problem, being the disease with the highest impact on
global health. Even with all the recent technological improvements, recurrence and …

Linking cellular stress responses to systemic homeostasis

L Galluzzi, T Yamazaki, G Kroemer - Nature Reviews Molecular Cell …, 2018 - nature.com
Mammalian cells respond to stress by activating mechanisms that support cellular functions
and hence maintain microenvironmental and organismal homeostasis. Intracellular …

Immunomodulatory nanosystems

X Feng, W Xu, Z Li, W Song, J Ding… - Advanced science, 2019 - Wiley Online Library
Immunotherapy has emerged as an effective strategy for the prevention and treatment of a
variety of diseases, including cancer, infectious diseases, inflammatory diseases, and …

Salinomycin kills cancer stem cells by sequestering iron in lysosomes

TT Mai, A Hamaï, A Hienzsch, T Cañeque, S Müller… - Nature …, 2017 - nature.com
Cancer stem cells (CSCs) represent a subset of cells within tumours that exhibit self-renewal
properties and the capacity to seed tumours. CSCs are typically refractory to conventional …

Acetyl coenzyme A: a central metabolite and second messenger

F Pietrocola, L Galluzzi, JM Bravo-San Pedro, F Madeo… - Cell metabolism, 2015 - cell.com
Acetyl-coenzyme A (acetyl-CoA) is a central metabolic intermediate. The abundance of
acetyl-CoA in distinct subcellular compartments reflects the general energetic state of the …