Epigenetic modulation and understanding of HDAC inhibitors in cancer therapy
The role of genetic and epigenetic factors in tumor initiation and progression is well
documented. Histone deacetylases (HDACs), histone methyl transferases (HMTs), and DNA …
documented. Histone deacetylases (HDACs), histone methyl transferases (HMTs), and DNA …
A machine learning approach to integrate big data for precision medicine in acute myeloid leukemia
Cancers that appear pathologically similar often respond differently to the same drug
regimens. Methods to better match patients to drugs are in high demand. We demonstrate a …
regimens. Methods to better match patients to drugs are in high demand. We demonstrate a …
Peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other cancers
M Andrea, T Weinschenk, V Goldfinger… - US Patent …, 2019 - Google Patents
The present invention relates to peptides, proteins, nucleic acids and cells for use in
immunotherapeutic methods. In particular, the present invention relates to the immuno …
immunotherapeutic methods. In particular, the present invention relates to the immuno …
Peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other cancers
M Andrea, T Weinschenk, V Goldfinger… - US Patent …, 2019 - Google Patents
The present invention relates to peptides, proteins, nucleic acids and cells for use in
immunotherapeutic methods. In particular, the present invention relates to the immuno …
immunotherapeutic methods. In particular, the present invention relates to the immuno …
FLASH protects ZEB1 from degradation and supports cancer cells' epithelial-to-mesenchymal transition
CF Abshire, JL Carroll, AM Dragoi - Oncogenesis, 2016 - nature.com
Cancer metastasis remains a significant challenge and the leading cause of cancer-
associated deaths. It is postulated that during metastasis cells undergo epithelial-to …
associated deaths. It is postulated that during metastasis cells undergo epithelial-to …
High occurrence of CRLF2 abnormalities in Mexican children with B-cell acute lymphoblastic leukemia
Abstract The P2RY8-CRLF2 and IGH-CRLF2 rearrangements induce the overexpression of
cytokine receptor-like factor 2 (CRLF2) and have been associated with relapse and poor …
cytokine receptor-like factor 2 (CRLF2) and have been associated with relapse and poor …
H2AFZ: A Novel Prognostic Marker in Canine Melanoma and a Predictive Marker for Resistance to CDK4/6 Inhibitor Treatment
L Bongiovanni, A Andriessen, S Silvestri… - Frontiers in Veterinary …, 2021 - frontiersin.org
Uncontrolled proliferation is a key feature of tumor progression and malignancy. This
suggests that cell-cycle related factors could be exploited as cancer biomarkers and that …
suggests that cell-cycle related factors could be exploited as cancer biomarkers and that …
[HTML][HTML] Dual role of CASP8AP2/FLASH in regulating epithelial-to-mesenchymal transition plasticity (EMP)
M Catalanotto, JM Vaz, C Abshire, R Youngblood… - Translational …, 2024 - Elsevier
Background Epithelial-to-mesenchymal transition (EMT) is a developmental program that
consists of the loss of epithelial features concomitant with the acquisition of mesenchymal …
consists of the loss of epithelial features concomitant with the acquisition of mesenchymal …
Histone 2A family member j drives mesenchymal transition and temozolomide resistance in glioblastoma multiforme
HH Lee, CH Lin, HY Lin, CH Kuei, JQ Zheng, YH Wang… - Cancers, 2019 - mdpi.com
Glioblastoma multiforme (GBM) is the most aggressive brain tumor and has a poor
prognosis and is poorly sensitive to radiotherapy or temozolomide (TMZ) chemotherapy …
prognosis and is poorly sensitive to radiotherapy or temozolomide (TMZ) chemotherapy …
Prognostic utility of key copy number alterations in T cell acute lymphoblastic leukemia
T‐cell acute lymphoblastic leukemia (T‐ALL) is a genetically heterogeneous disease,
characterized by an abnormal transformation of T cells into highly proliferative leukemic …
characterized by an abnormal transformation of T cells into highly proliferative leukemic …