Tissue fibrosis induced by radiotherapy: current understanding of the molecular mechanisms, diagnosis and therapeutic advances
Z Yu, C Xu, B Song, S Zhang, C Chen, C Li… - Journal of Translational …, 2023 - Springer
Cancer remains the leading cause of death around the world. In cancer treatment, over 50%
of cancer patients receive radiotherapy alone or in multimodal combinations with other …
of cancer patients receive radiotherapy alone or in multimodal combinations with other …
Clinical, mechanistic, and therapeutic landscape of cutaneous fibrosis
When dysregulated, skin fibrosis can lead to a multitude of pathologies. We provide a
framework for understanding the wide clinical spectrum, mechanisms, and management of …
framework for understanding the wide clinical spectrum, mechanisms, and management of …
[HTML][HTML] Iron deposition-induced ferroptosis in alveolar type II cells promotes the development of pulmonary fibrosis
H Cheng, D Feng, X Li, L Gao, S Tang, W Liu… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Ferroptosis is a newly discovered type of regulated cell death, characterized by the iron-
dependent accumulation of lipid reactive oxygen species, which has been implicated in …
dependent accumulation of lipid reactive oxygen species, which has been implicated in …
Transdermal deferoxamine administration improves excisional wound healing in chronically irradiated murine skin
Background Radiation-induced skin injury is a well-known risk factor for impaired wound
healing. Over time, the deleterious effects of radiation on skin produce a fibrotic …
healing. Over time, the deleterious effects of radiation on skin produce a fibrotic …
Role of ferroptosis in radiation-induced soft tissue injury
Ionizing radiation has been pivotal in cancer therapy since its discovery. Despite its
therapeutic benefits, IR causes significant acute and chronic complications due to DNA …
therapeutic benefits, IR causes significant acute and chronic complications due to DNA …
Phytochemicals: potential therapeutic modulators of radiation induced signaling pathways
Ionizing radiation results in extensive damage to biological systems. The massive amount of
ionizing radiation from nuclear accidents, radiation therapy (RT), space exploration, and the …
ionizing radiation from nuclear accidents, radiation therapy (RT), space exploration, and the …
Radiation-induced tissue damage: clinical consequences and current treatment options
H Nepon, T Safran, EM Reece… - Seminars in Plastic …, 2021 - thieme-connect.com
Radiation therapy is a valuable tool in the treatment of numerous malignancies but, in
certain cases, can also causes significant acute and chronic damage to noncancerous …
certain cases, can also causes significant acute and chronic damage to noncancerous …
Chelating the valley of death: Deferoxamine's path from bench to wound clinic
There is undisputable benefit in translating basic science research concretely into clinical
practice, and yet, the vast majority of therapies and treatments fail to achieve approval. The …
practice, and yet, the vast majority of therapies and treatments fail to achieve approval. The …
Strategies to minimize surgical scarring: translation of lessons learned from bedside to bench and back
UM Parikh, J Mentz, I Collier, MJ Davis… - Advances in Wound …, 2022 - liebertpub.com
Significance: An understanding of the physiology of wound healing and scarring is
necessary to minimize surgical scar formation. By reducing tension across the healing …
necessary to minimize surgical scar formation. By reducing tension across the healing …
Radiation-induced skin reactions: oxidative damage mechanism and antioxidant protection
C Liu, J Wei, X Wang, Q Zhao, J Lv, Z Tan… - Frontiers in Cell and …, 2024 - frontiersin.org
According to official statistics, cancer remains the main reason of death and over 50% of
patients with cancer receive radiotherapy. However, adverse consequences after radiation …
patients with cancer receive radiotherapy. However, adverse consequences after radiation …