Inositol pyrophosphates as versatile metabolic messengers
Discovered in 1993, inositol pyrophosphates are evolutionarily conserved signaling
metabolites whose versatile modes of action are being increasingly appreciated. These …
metabolites whose versatile modes of action are being increasingly appreciated. These …
The inositol phosphate signalling network in physiology and disease
Combinatorial substitution of phosphate groups on the inositol ring gives rise to a plethora of
inositol phosphates (InsPs) and inositol pyrophosphates (PP-InsPs). These small molecules …
inositol phosphates (InsPs) and inositol pyrophosphates (PP-InsPs). These small molecules …
HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly
HIV-1 Gag metamorphoses inside each virion, from an immature lattice that forms during
viral production to a mature capsid that drives infection. Here we show that the immature …
viral production to a mature capsid that drives infection. Here we show that the immature …
The enzymatic activity of inositol hexakisphosphate kinase controls circulating phosphate in mammals
Y Moritoh, S Abe, H Akiyama, A Kobayashi… - Nature …, 2021 - nature.com
Circulating phosphate levels are tightly controlled within a narrow range in mammals. By
using a novel small-molecule inhibitor, we show that the enzymatic activity of inositol …
using a novel small-molecule inhibitor, we show that the enzymatic activity of inositol …
ITPK1 is an InsP6/ADP phosphotransferase that controls phosphate signaling in Arabidopsis
In plants, phosphate (P i) homeostasis is regulated by the interaction of PHR transcription
factors with stand-alone SPX proteins, which act as sensors for inositol pyrophosphates. In …
factors with stand-alone SPX proteins, which act as sensors for inositol pyrophosphates. In …
Flux regulation through glycolysis and respiration is balanced by inositol pyrophosphates in yeast
Although many prokaryotes have glycolysis alternatives, it's considered as the only energy-
generating glucose catabolic pathway in eukaryotes. Here, we managed to create a hybrid …
generating glucose catabolic pathway in eukaryotes. Here, we managed to create a hybrid …
Analytical methods for determination of phytic acid and other inositol phosphates: A review
G Marolt, M Kolar - Molecules, 2020 - mdpi.com
From the early precipitation-based techniques, introduced more than a century ago, to the
latest development of enzymatic bio-and nano-sensor applications, the analysis of phytic …
latest development of enzymatic bio-and nano-sensor applications, the analysis of phytic …
Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1, 5-IP8 and the SPX domain of Pho81
Eukaryotic cells control inorganic phosphate to balance its role as essential macronutrient
with its negative bioenergetic impact on reactions liberating phosphate. Phosphate …
with its negative bioenergetic impact on reactions liberating phosphate. Phosphate …
Intracellular phosphate sensing and regulation of phosphate transport systems in plants
Z Wang, HF Kuo, TJ Chiou - Plant Physiology, 2021 - academic.oup.com
Recent research on the regulation of cellular phosphate (Pi) homeostasis in eukaryotes has
collectively made substantial advances in elucidating inositol pyrophosphates (PP-InsP) as …
collectively made substantial advances in elucidating inositol pyrophosphates (PP-InsP) as …
Capillary electrophoresis mass spectrometry identifies new isomers of inositol pyrophosphates in mammalian tissues
Technical challenges have to date prevented a complete profiling of the levels of myo-
inositol phosphates (InsPs) and pyrophosphates (PP-InsPs) in mammalian tissues. Here, we …
inositol phosphates (InsPs) and pyrophosphates (PP-InsPs) in mammalian tissues. Here, we …