Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising
vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital components of …

The fluid mosaic model of Singer and Nicolson (1972) is a commonly used representation of
the cell membrane structure and dynamics. However a number of features, the result of four …

Lipid nanoparticle (LNP) packaged mRNA vaccines have been deployed against infectious
diseases such as COVID-19, yet their structural features remain unclear. Cholesterol, a …

Hydrostatic pressure increases with depth in the ocean, but little is known about the
molecular bases of biological pressure tolerance. We describe a mode of pressure …

Studies of membrane proteins have revealed a direct link between the lipid environment and
the structure and function of some of these proteins. Although some of these effects involve …

The activities of integral membrane proteins are often affected by the structures of the lipid
molecules that surround them in the membrane. One important parameter is the …

Techniques for freezing bull sperm developed over the past 40 years have not yielded
protocols for preserving sperm from other species. Recent advances in our understanding of …

Docosahexaenoic acid (DHA) with 22-carbons and 6 double bonds is the extreme example
of an ω-3 polyunsaturated fatty acid (PUFA). DHA has strong medical implications since its …

The lipid bilayer component of biological membranes is important for the distribution,
organization, and function of bilayer-spanning proteins. This regulation is due to both …

Lipid molecules bound to membrane proteins are resolved in some high-resolution
structures of membrane proteins. An analysis of these structures provides a framework …