The mitotic spindle has a crucial role in ensuring the accurate segregation of chromosomes
into the two daughter cells during cell division, which is paramount for maintaining genome …

The tumor oncoproteins HRAS, KRAS, and NRAS are the founding members of a larger
family of at least 35 related human proteins. Using a somewhat broader definition of …

During cell division, mitotic spindles are assembled by microtubule-based motor proteins,.
The bipolar organization of spindles is essential for proper segregation of chromosomes …

Macromolecular transport between the cytoplasm and the nucleus occurs through the
nuclear pore complex (NPC) and is mediated by multiple families of soluble transport …

The Aurora protein kinase family (consisting of Aurora-A,-B and-C) is an important group of
enzymes that controls several aspects of cell division in mammalian cells. Dysfunction of …

Despite their overwhelming complexity, living cells display a high degree of internal
mechanical and functional organization which can largely be attributed to the intracellular …

Abstract The small nuclear GTPase Ran controls the directionality of macromolecular
transport between the nucleus and the cytoplasm. Ran also has important roles during …

Cell division is enacted by a microtubule-based, self-assembling macromolecular machine
known as the mitotic spindle. In 1986, Kirschner and Mitchison proposed that by undergoing …

The mitotic spindle is the macromolecular machine that segregates chromosomes to two
daughter cells during mitosis. The major structural elements of the spindle are microtubule …

The mitotic spindle is a highly dynamic molecular machine composed of tubulin, motors, and
other molecules. It assembles around the chromosomes and distributes the duplicated …