The ubiquitin-proteasome system (UPS) and autophagy are the two major intracellular
protein quality control (PQC) pathways that are responsible for cellular proteostasis …

Anionic lipids act as signals for the recruitment of proteins containing cationic clusters to
biological membranes. A family of anionic lipids known as the phosphoinositides (PIPs) are …

Through a network of progressively maturing vesicles, the endosomal system connects the
cell's interior with extracellular space. Intriguingly, this network exhibits a bilateral …

Selective ubiquitin-dependent autophagy plays a pivotal role in the elimination of protein
aggregates, assemblies, or organelles and counteracts the cytotoxicity of proteins linked to …

Tuberculosis, one of the leading causes of death worldwide, stimulates inflammatory
responses with beneficial and pathologic consequences. The regulation and nature of an …

Endoplasmic reticulum (ER) proteostasis is maintained by various catabolic pathways.
Lysosomes clear entire ER portions by ER‐phagy, while proteasomes selectively clear …

The Toll-interacting protein (Tollip) is a critical regulator of Toll-like receptor (TLR)-mediated
innate immune responses. Tollip modulates TLR signaling and membrane trafficking …

Zebrafish model systems for infectious disease are increasingly used for the functional
analysis of molecular pattern recognition processes. These studies benefit from the high …

Innate leukocytes manifest dynamic and distinct inflammatory responses upon challenges
with rising dosages of pathogen-associated molecular pattern molecules such as …

Toll-interacting protein (TOLLIP) is a ubiquitous intracellular adaptor protein involved in
multiple intracellular signaling pathways. It plays a key role in mediating inflammatory …