Cancer cells undergo metabolic alterations to meet the immense demand for energy,
building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting …

Tumor cells must generate sufficient ATP and biosynthetic precursors in order to maintain
cell proliferation requirements. Otto Warburg showed that tumor cells uptake high amounts …

The presence of lactate in human tumours has been long neglected, confined to the role of a
waste product derived from glycolysis and as a biomarker of malignancy. More recently …

Carbonic anhydrases IX and CAXII (CAIX/CAXII) are transmembrane zinc metalloproteins
that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide …

Acidosis is a fundamental feature of the tumor microenvironment, which directly regulates
tumor cell invasion by affecting immune cell function, clonal cell evolution, and drug …

Simple Summary Almost a century ago, Nobel Prize laureate Otto Warburg realized that
cancer cells consumed much more glucose than normal cells and also produced large …

Over the last decades, the incidence of human papilloma virus (HPV) positive head and
neck squamous-cell carcinoma (HNSCC) has significantly increased. Infection with high-risk …

Glucose metabolism is a mechanism by which energy is produced in form of adenosine
triphosphate (ATP) by mitochondria and precursor metabolites are supplied to enable the …

Recent evidence has emerged that cancer cells can use various metabolites as fuel
sources. Restricting cultured cancer cells to sole metabolite fuel sources can promote …

Simple Summary Lactic acidosis is a prominent feature of the tumour microenvironment and
a key player in cancer metabolism. This review is aimed at combining the mechanisms …