The MEK5/ERK5 mitogen-activated protein kinases (MAPK) cascade is a unique signaling
module activated by both mitogens and stress stimuli, including cytokines, fluid shear stress …

Transforming growth factor beta (TGFβ) is named for the function it was originally discovered
to perform-transformation of normal cells into aggressively growing malignant cells. It …

Atherosclerosis is commonly known as an inflammatory disease that is characterized by lipid
deposition in the arterial wall, causing gradual restriction or complete blockade of blood …

The endothelium, the monolayer of endothelial cells that line blood vessels, is exposed to a
number of mechanical forces, including frictional shear flow, pulsatile stretching and …

Artery stenosis is a common cause of hypertension and stroke and can be due to
atherosclerosis accumulation in the majority of cases and in a small fraction of patients to …

Myogenesis is an essential process that can affect the yield and quality of beef.
Transcriptional studies have shown that histone deacetylase 11 (HDAC11) was differentially …

In this perspective, we discussed emerging data indicating a role for Notch signalling in
inherited disorders of the heart failure with focus on hypertrophic cardiomyopathy (HCM) …

BACKGROUND: Atherosclerosis preferentially occurs in arterial regions of disturbed blood
flow, and stable flow (s-flow) protects against atherosclerosis by incompletely understood …

Current dogma dictates that, during adulthood, endothelial cells (ECs) are locked in an
immutable stable homeostatic state. By contrast, herein we show that maintenance of EC …

Transcription factors (TFs) play a crucial role in regulating the dynamic and precise patterns
of gene expression required for the initial specification of endothelial cells (ECs), and during …