Advances in cell membrane chromatography
Cell membrane chromatography (CMC) is a biomimetic chromatographic method based on
the ability of membrane receptors to selectively interact with their ligands in vivo. Using …
the ability of membrane receptors to selectively interact with their ligands in vivo. Using …
[HTML][HTML] Overview of the detection methods for equilibrium dissociation constant KD of drug-receptor interaction
W Ma, L Yang, L He - Journal of pharmaceutical analysis, 2018 - Elsevier
Drug-receptor interaction plays an important role in a series of biological effects, such as cell
proliferation, immune response, tumor metastasis, and drug delivery. Therefore, the …
proliferation, immune response, tumor metastasis, and drug delivery. Therefore, the …
Characterization of the binding properties of molecularly imprinted polymers
<? xm-replace_text {Heading}?> Abstract The defining characteristic of the binding sites of
any particular molecularly imprinted material is heterogeneity: that is, they are not all …
any particular molecularly imprinted material is heterogeneity: that is, they are not all …
A general strategy for protein affinity-ligand oriented-immobilization and screening for bioactive compounds
Y Yi, K Shi, S Ding, J Hu, C Zhang, J Mei… - … of Chromatography B, 2023 - Elsevier
Natural products containing complex mixtures of potentially bioactive compounds are a
major source of new drugs, however, conventional screening for active compounds is a time …
major source of new drugs, however, conventional screening for active compounds is a time …
Acetylcholinesterase immobilized capillary reactors–tandem mass spectrometry: an on-flow tool for ligand screening
The use of immobilized capillary enzyme reactors (ICERs) for online ligand screening has
been adopted as a new technique for high-throughput screening (HTS). In this work, the …
been adopted as a new technique for high-throughput screening (HTS). In this work, the …
Solid-supported proteins in the liquid chromatography domain to probe ligand-target interactions
Ligand-target interactions play a central role in drug discovery processes because these
interactions are crucial in biological systems. Small molecules-proteins interactions can …
interactions are crucial in biological systems. Small molecules-proteins interactions can …
Miniaturized weak affinity chromatography for ligand identification of nanodiscs-embedded G-protein coupled receptors
Biophysical techniques that enable the screening and identification of weak affinity
fragments against a target protein are at the heart of Fragment Based Drug Design …
fragments against a target protein are at the heart of Fragment Based Drug Design …
High-performance affinity chromatography: applications in drug–protein binding studies and personalized medicine
The binding of drugs with proteins and other agents in serum is of interest in personalized
medicine because this process can affect the dosage and action of drugs. The extent of this …
medicine because this process can affect the dosage and action of drugs. The extent of this …
Analytical methods for the analysis of volatile natural products
Y Li - Natural Product Reports, 2023 - pubs.rsc.org
Covering: 2000 to 2022 This article reviews the latest developments of analytical methods of
volatile natural products. Volatile organic compounds (VOCs) released from biological …
volatile natural products. Volatile organic compounds (VOCs) released from biological …
Recent application of analytical methods to phase I and phase II drugs development: A review
Drug development is a time‐consuming and costly process. It is usually divided into four
phases, although it is not always possible to draw a sharp line between the various stages …
phases, although it is not always possible to draw a sharp line between the various stages …