Synthesis, crystal structure, Hirshfeld surface analysis, DFT, molecular docking and in vitro antitumor studies of (2E)-2-[4-(diethylamino) benzylidene]-N …

K Preetha, EB Seena, PK Maniyampara… - Journal of Molecular …, 2024 - Elsevier
The crystal structure and spectral characterization of a new proligand,(2E)-2-[4-
(diethylamino) benzylidene]-N-ethylhydrazinecarbothioamide is described. The compound …

Thiosemicarbazone ligands based transition metal complexes: A multifaceted investigation of antituberculosis, anti‐inflammatory, antibacterial, antifungal activities …

B Kumar, J Devi, A Dubey, N Tufail… - Applied …, 2024 - Wiley Online Library
Infectious diseases have held a prominent place in the history of humanity, sha**
societies, influencing medical advances, and affecting the lives of individuals on a global …

Biomolecular Interactions and Anticancer Mechanisms of Ru (II)-Arene Complexes of Cinnamaldehyde-Derived Thiosemicarbazone Ligands: Analysis Combining In …

VN Vadakkedathu Palakkeezhillam… - ACS Applied Bio …, 2024 - ACS Publications
Our study focuses on synthesizing and exploring the potential of three N-(4) substituted
thiosemicarbazones derived from cinnamic aldehyde, alongside their Ru (II)-(η6-p …

Expression of PPAR-γ TF by newly synthesized thiazolidine-2, 4-diones to manage glycemic control: Insights from in silico, in vitro and experimental pharmacology in …

S Gharge, SG Alegaon, SD Ranade, RS Kavalapure… - Bioorganic …, 2024 - Elsevier
In pursuit of novel antidiabetic agents to combat type II diabetes mellitus, our study focused
on identifying pharmacophoric features responsible for PPAR-γ expression, a key regulator …

DNA and albumin interaction studies of imidazole-based thiosemicarbazone-metal (II) chelates using spectroscopic and molecular docking methods: DNA cleavage …

S Kathiresan, MP Kesavan, J Annaraj, L Ravi - Inorganic Chemistry …, 2023 - Elsevier
In this research article, we present our findings on the successful chemical synthesis of a
novel thiosemicarbazone ligand (L) based on imidazole and its spectral characterizations …

Syntheses and coordination chemistry of thiosemicarbazone-based titanium complexes

K Schwitalla, M Claußen, M Schmidtmann… - New Journal of …, 2024 - pubs.rsc.org
Two routes leading to thiosemicarbazone-based complexes are reported with the view of
develo** ionic titanium complexes as cytotoxic metallodrugs. The reaction of bis (π-η5: σ …

Manganese (III) complexes with a tetradentate thiosemicarbazone. Structural characterization, electrochemistry, antioxidant capability, molecular docking and …

S Ortaboy, T Karakurt, B Kaya, O Şahin, B Ülküseven - Polyhedron, 2024 - Elsevier
Two manganese (III) complexes with the general formula [Mn III (L) X](where L is a
tetradentate thiosemicarbazone; X= Cl (Mn1) or N 3 (Mn2 is new) were synthesized and …

Ligand Many-Body Expansion as a General Approach for Accelerating Transition Metal Complex Discovery

DBK Chu, DA González-Narváez, R Meyer… - Journal of Chemical …, 2024 - ACS Publications
Methods that accelerate the evaluation of molecular properties are essential for chemical
discovery. While some degree of ligand additivity has been established for transition metal …

Mechanistic insights and in vivo efficacy of thiosemicarbazones against methicillin-resistant Staphylococcus aureus

A Gaudreau, DW Watson, RS Flannagan, P Roy… - Journal of Biological …, 2024 - jbc.org
Staphylococcus aureus poses a significant threat in both community and hospital settings
due to its infective and pathogenic nature combined with its ability to resist the action of …

Novel rhodanine–thiazole hybrids as potential antidiabetic agents: a structure-based drug design approach

S Gharge, SG Alegaon, SD Ranade… - RSC Medicinal …, 2025 - pubs.rsc.org
New rhodanine–thiazole clubbed compounds (7a–7l) were synthesised and characterised
with various spectroscopy methods. The synthesised hybrids underwent in vitro HPA, HLAG …