The cytochrome P450 (CYP) enzyme family is the most important enzyme system catalyzing
the phase 1 metabolism of pharmaceuticals and other xenobiotics such as herbal remedies …

Proton pump inhibitors (PPIs) are used extensively for the treatment of gastric acid-related
disorders, often over the long term, which raises the potential for clinically significant drug …

Nearly 25% of US adults report concurrently taking a prescription medication with a dietary
supplement. Some supplements, such as St. John's wort and goldenseal, are known to …

The concomitant use of herbal medicines and pharmacotherapy is wide spread. We have
reviewed the literature to determine the possible interactions between seven popular herbal …

Benzodiazepines (BZDs) remain important agents in the management of epilepsy. They are
drugs of first choice for status epilepticus and seizures associated with post‐anoxic insult …

Variability of drug metabolism, especially that of the most important phase I enzymes or
cytochrome P450 (CYP) enzymes, is an important complicating factor in many areas of …

Purpose Interest in the use of herbal products has grown dramatically in the Western world.
Recent estimates suggest an overall prevalence for herbal preparation use of 13% to 63 …

This article provides an overview of the clinical evidence of interactions between herbal and
conventional medicines. Herbs involved in drug interactions–or that have been evaluated in …

Abstract Background Proton pump inhibitors (PPIs) represent drugs of first choice for treating
peptic ulcer, Helicobacter pylori infection, gastrooesophageal reflux disease, nonsteroidal …

St John's wort (SJW) extracts, prepared from the aerial parts of Hypericum perforatum,
contain numerous pharmacologically active ingredients, including naphthodianthrones (eg …