Protein kinase A (PKA) is a central regulator of cardiac performance and morphology.
Myocardial PKA activation is induced by a variety of hormones, neurotransmitters, and stress …

Cardiovascular disease (CVD) is a major cause of morbidity and mortality worldwide.
Compared to traditional therapeutic strategies, three-dimensional (3D) bioprinting is one of …

Heart failure (HF) describes a heterogenous complex spectrum of pathological conditions
that results in structural and functional remodeling leading to subsequent impairment of …

Over the past decade, endoplasmic reticulum (ER) stress has emerged as an important
mechanism involved in the pathogenesis of cardiovascular diseases including heart failure …

Increasing evidence indicates the involvement of myocardial oxidative injury and
mitochondrial dysfunction in the pathophysiology of heart failure (HF). Alpha-ketoglutarate …

Pharmacologic activation of stress-responsive signaling pathways provides a promising
approach for ameliorating imbalances in proteostasis associated with diverse diseases …

High levels of circulating catecholamines cause cardiac injury, pathological remodeling, and
heart failure, but the underlying mechanisms remain elusive. Here we provide both in vitro …

Background: Cardiac contractile function requires high energy from mitochondria, and Ca2+
from the sarcoplasmic reticulum (SR). Via local Ca2+ transfer at close mitochondria-SR …

Dysregulated amino acid increases the risk for heart failure (HF) via unclear mechanisms.
Here, we find that increased plasma tyrosine and phenylalanine levels are associated with …

Acute pancreatitis (AP) is one of the common acute abdominal inflammatory diseases in
clinic with acute onset and rapid progress. About 20% of the patients will eventually develop …