Small RNAs in bacteria and archaea: who they are, what they do, and how they do it
Small RNAs are ubiquitously present regulators in all kingdoms of life. Most bacterial and
archaeal small RNAs (sRNAs) act by antisense mechanisms on multiple target mRNAs …
archaeal small RNAs (sRNAs) act by antisense mechanisms on multiple target mRNAs …
Hfq chaperone brings speed dating to bacterial sRNA
A Santiago‐Frangos… - Wiley Interdisciplinary …, 2018 - Wiley Online Library
Hfq is a ubiquitous, Sm‐like RNA binding protein found in most bacteria and some archaea.
Hfq binds small regulatory RNAs (sRNAs), facilitates base pairing between sRNAs and their …
Hfq binds small regulatory RNAs (sRNAs), facilitates base pairing between sRNAs and their …
Unraveling RNA conformation dynamics in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episode syndrome with solid-state nanopores
This study investigates transfer ribonucleic acid (tRNA) conformational dynamics in the
context of MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like …
context of MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like …
Positive regulation by small RNAs and the role of Hfq
T Soper, P Mandin, N Majdalani… - Proceedings of the …, 2010 - National Acad Sciences
Bacterial small noncoding RNAs carry out both positive and negative regulation of gene
expression by pairing with mRNAs; in Escherichia coli, this regulation often requires the …
expression by pairing with mRNAs; in Escherichia coli, this regulation often requires the …
The Single-Nucleotide Resolution Transcriptome of Pseudomonas aeruginosa Grown in Body Temperature
One of the hallmarks of opportunistic pathogens is their ability to adjust and respond to a
wide range of environmental and host-associated conditions. The human pathogen …
wide range of environmental and host-associated conditions. The human pathogen …
Modulation of pre-mRNA structure by hnRNP proteins regulates alternative splicing of MALT1
AN Jones, C Graß, I Meininger, A Geerlof… - Science …, 2022 - science.org
Alternative splicing plays key roles for cell type–specific regulation of protein function. It is
controlled by cis-regulatory RNA elements that are recognized by RNA binding proteins …
controlled by cis-regulatory RNA elements that are recognized by RNA binding proteins …
C-terminal domain of the RNA chaperone Hfq drives sRNA competition and release of target RNA
The bacterial Sm protein and RNA chaperone Hfq stabilizes small noncoding RNAs
(sRNAs) and facilitates their annealing to mRNA targets involved in stress tolerance and …
(sRNAs) and facilitates their annealing to mRNA targets involved in stress tolerance and …
Proteins that chaperone RNA regulation
ABSTRACT RNA-binding proteins chaperone the biological functions of noncoding RNA by
reducing RNA misfolding, improving matchmaking between regulatory RNA and targets, and …
reducing RNA misfolding, improving matchmaking between regulatory RNA and targets, and …
RNAs actively cycle on the Sm-like protein Hfq
Hfq, a protein required for small RNA (sRNA)-mediated regulation in bacteria, binds RNA
with low-nanomolar Kd values and long half-lives of complexes (> 100 min). This cannot be …
with low-nanomolar Kd values and long half-lives of complexes (> 100 min). This cannot be …
The core and accessory Hfq interactomes across Pseudomonas aeruginosa lineages
The major RNA-binding protein Hfq interacts with mRNAs, either alone or together with
regulatory small noncoding RNAs (sRNAs), affecting mRNA translation and degradation in …
regulatory small noncoding RNAs (sRNAs), affecting mRNA translation and degradation in …