Background The three-dimensional organization of the genome is tightly connected to its
biological function. The Hi-C approach was recently introduced as a method that can be …

Pluripotent cells, such as embryonic stem (ES) cells, embryonic germ cells and embryonic
carcinoma cells are a unique type of cell because they remain undifferentiated indefinitely in …

Topologically associated domains (TADs) restrict promoter-enhancer interactions, thereby
maintaining the spatiotemporal pattern of gene activity. However, rearrangements of the …

Copy number variations (CNVs) of the human CNTN6 gene caused by megabase-scale
microdeletions or microduplications in the 3p26. 3 region are often the cause of …

Most cardiomyocytes (CMs) in the adult mammalian heart are either binucleated or contain a
single polyploid nucleus. Recent studies have shown that polyploidy in CMs plays an …

Modeling of neurodegenerative diseases in vitro holds great promise for biomedical
research. Human cell lines harboring a mutations in disease-causing genes are thought to …

In a previous study using one-step CRISPR/Cas9 genome editing in mouse zygotes, we
created five founders carrying a 1,137 kb deletion and two founders carrying the same …

One of the most productive strategies for finding the functions of proteins is to study the
consequences of loss of protein function. For this purpose, cells or organisms with a …

Alterations of human karyotype caused by chromosomal rearrangements are often
associated with considerable phenotypic effects. Studying molecular mechanisms …

This review is focused on recent advances in fusion-based reprogramming of cells of
different pluripotent statuses or lineage origins. Recent findings are discussed from …