The liver is a central organ for homeostasis with unique regenerative capacities. Mature
hepatocytes possess a remarkable capacity to proliferate upon injury, challenging efforts to …

Extracellular vesicles (EV s), membrane vesicles that are secreted by a variety of
mammalian cell types, have been shown to play an important role in intercellular …

A challenge for advancing approaches to liver regeneration is loss of functional
differentiation capacity when hepatocyte progenitors are maintained in culture. Recent …

The cellular and molecular events regulating the induction and tissue-specific differentiation
of endoderm are central to our understanding of the development and function of many …

Hepatocytes, like other epithelia, are situated at the interface between the organism's
exterior and the underlying internal milieu and organize the vectorial exchange of …

Embryonic stem cells (ES cells), bone marrow-derived mesenchymal stem cells, umbilical
cord blood-derived mesenchymal stem cells, and hepatic stem cells in liver have been …

ABSTRACT A self-organizing organoid model provides a new approach to study the
mechanism of human liver organogenesis. Previous animal models documented that …

Background & Aims Currently, much effort is directed towards the development of new cell
sources for clinical therapy using cell fate conversion by small molecules. Direct lineage …

Techniques for reprogramming somatic cells create new opportunities for drug screening,
disease modeling, artificial organ development, and cell therapy. The development of …

Hepatic oval cells are considered to be facultative hepatic stem cells (HSCs) that
differentiate into hepatocytes and cholangiocytes in severely injured liver. Hepatic oval cells …