Head and neck cancer is the sixth most common cancer across the globe. This is generally
associated with tobacco and alcohol consumption. Cancer in the pharynx majorly arises …

Head and neck squamous cell carcinoma (HNSCC) is among the most prevalent cancer
worldwide, with the most severe impact on quality of life of patients. Despite the …

Aerobic glycolysis is one of the hallmarks of human cancer cells. Overexpression of
hexokinase 2 (HK2) plays a crucial role in the maintaining of unlimited tumor cell growth. In …

Dysregulated metabolism is a hallmark of cancer that manifests through alterations in
bioenergetic and biosynthetic pathways to enable tumor cell proliferation and survival …

Cancer-associated fibroblasts (CAFs) are involved in critical aspects of head and neck
squamous cell carcinoma (HNSCC) pathogenesis, such as the formation of a tumor …

Non-small cell lung cancer (NSCLC) is characterized by several molecular alterations that
contribute to its development and progression. These alterations include the epidermal …

Despite a dearth of activating driver mutations in head and neck squamous cell carcinoma
(HNSCC), aberrant activation of the oncogenes, epidermal growth factor receptor (EGFR) …

The enzyme pyruvate kinase M2 (PKM2) plays a major role in the switch of tumor cells from
oxidative phosphorylation to aerobic glycolysis, one of the hallmarks of cancer. Different …

Abstract Protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the
regulation of apoptosis, proliferation, and DNA-damage response, is overexpressed in many …

The emergence of immune checkpoint inhibitors (ICIs) has revolutionized the treatment of
recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). Biomarkers …