The life of bacteria is challenging, to endure bacteria employ a range of mechanisms to
optimize their environment, including deploying the type VI secretion system (T6SS). Acting …

Contact-dependent growth inhibition (CDI) is a widespread form of inter-bacterial
competition mediated by CdiA effector proteins. CdiA is presented on the inhibitor cell …

Protein secretion systems are critical macromolecular machines employed by bacteria to
interact with diverse environments and hosts during their life cycle. Cytosolically produced …

Bacteria use the type VI secretion system (T6SS) to secrete toxins into pro-and eukaryotic
cells via machinery consisting of a contractile sheath and a rigid tube. Rearrangement …

Bacterial type VI secretion systems (T6SSs) are puncturing molecular machines that
transport effector proteins to kill microbes, manipulate eukaryotic cells, or facilitate nutrient …

The type VI secretion system (T6SS) is an important mediator of microbe–microbe and
microbe–host interactions. Gram-negative bacteria use the T6SS to inject T6SS effectors …

Bacterial competition is a significant driver of toxin polymorphism, which allows continual
compensatory evolution between toxins and the resistance developed to overcome their …

Diverse marine animals undergo a metamorphic larval-to-juvenile transition in response to
surface-bound bacteria. Although this host-microbe interaction is critical to establishing and …

Peptidoglycan is a major constituent of the bacterial cell wall. Its integrity as a polymeric
edifice is critical for bacterial survival and, as such, it is a preeminent target for antibiotics …

We present an in-depth electrophysiological analysis of Tse5, a pore-forming toxin (PFT)
delivered by the type VI secretion system (T6SS) of Pseudomonas aeruginosa. The T6SS is …