Atherosclerosis is a multifocal alteration of the vascular wall of medium and large arteries
characterized by a local accumulation of cholesterol and non-resolving inflammation …

Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

Oxidative cyclizations are important transformations that occur widely during natural product
biosynthesis. The transformations from acyclic precursors to cyclized products can afford …

Targeted protein degradation (TPD) has been established as a viable alternative to
attenuate the function of a specific protein of interest in both biological and clinical contexts …

A Hybrid drug which comprises the incorporation of two drug pharmacophores in one single
molecule are basically designed to interact with multiple targets or to amplify its effect …

Angiogenesis has become an attractive target for drug therapy because of its key role in
tumor growth. An extensive array of compounds is currently in preclinical development, with …

To determine whether angiogenesis is necessary for normal alveolarization, we studied the
effects of two antiangiogenic agents, thalidomide and fumagillin, on alveolarization during a …

Covering: 31st December 2004Natural product and natural product-derived compounds that
are being evaluated in clinical trials or in registration (current 31 December 2004) have …

Recent studies have established distinctive serum polypeptide patterns through mass
spectrometry (MS) that reportedly correlate with clinically relevant outcomes. Wider …

Some of the most widely used drugs, such as aspirin and penicillin, are covalent drugs.
Covalent binding can improve potency, selectivity, and duration of the effects, but the …