Simple Summary Rhabdomyosarcoma (RMS) is a rare pediatric sarcoma affecting skeletal
muscle in children and young adults. It is responsible for 3% of all childhood malignant …

Phosphatidylinositol-3 kinases, PI3Ks, constitute a lipid kinase family characterized by their
ability to phosphorylate inositol ring 3′-OH group in inositol phospholipids to generate the …

Children and adolescents with rhabdomyosarcoma (RMS) comprise a heterogeneous
population with variable overall survival rates ranging between approximately 6% and 100 …

Mammalian target of rapamycin (mTOR) is a kinase that functions as a master switch
between catabolic and anabolic metabolism and as such is a target for the design of …

Evading apoptosis is considered to be a hallmark of cancer, because mutations in apoptotic
regulators invariably accompany tumorigenesis. Many chemotherapeutic agents induce …

Cardiovascular diseases (CVDs) are the major causes of death in the western world. The
incidence of cardiovascular disease as well as the rate of cardiovascular mortality and …

The resistance of many types of cancer to conventional chemotherapies is a major factor
undermining successful cancer treatment. In this review, the role of a signal transduction …

The mammalian target of rapamycin (mTOR) coordinates cell growth with thegrowth factor
and nutrient/energy status of the cell. The phosphatidylinositol3-kinase-AKT pathway is …

Rapamycin and its derivatives (CCI-779, RAD001 and AP23576) are immunosuppressor
macrolides that block mTOR (mammalian target of rapamycin) functions and yield …

The mTOR pathway was discovered in the late 1970s after the compound and natural
inhibitor of mTOR, rapamycin was isolated from the bacterium Streptomyces hygroscopicus …