Tumor metastasis: moving new biological insights into the clinic
As the culprit behind most cancer-related deaths, metastasis is the ultimate challenge in our
effort to fight cancer as a life-threatening disease. The explosive growth of metastasis …
effort to fight cancer as a life-threatening disease. The explosive growth of metastasis …
Novel approaches to target the microenvironment of bone metastasis
Bone metastases are a frequent and severe complication of advanced-stage cancers. Breast
and prostate cancers, the most common malignancies in women and men, respectively …
and prostate cancers, the most common malignancies in women and men, respectively …
Distinct functions of AKT isoforms in breast cancer: a comprehensive review
N Hinz, M Jücker - Cell Communication and Signaling, 2019 - Springer
Background AKT, also known as protein kinase B, is a key element of the PI3K/AKT
signaling pathway. Moreover, AKT regulates the hallmarks of cancer, eg tumor growth …
signaling pathway. Moreover, AKT regulates the hallmarks of cancer, eg tumor growth …
The role of the tumor-microenvironment in lung cancer-metastasis and its relationship to potential therapeutic targets
Non-small cell lung cancer (NSCLC) accounts for> 80% of lung cancer cases and currently
has an overall five-year survival rate of only 15%. Patients presenting with advanced stage …
has an overall five-year survival rate of only 15%. Patients presenting with advanced stage …
Tumor cell dissemination: emerging biological insights from animal models and cancer patients
Circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) are increasingly
recognized for their potential utility in disease monitoring and therapeutic targeting. The …
recognized for their potential utility in disease monitoring and therapeutic targeting. The …
The PI3K/AKT signaling pathway in regulatory T-cell development, stability, and function
SL Pompura, M Dominguez-Villar - Journal of leukocyte biology, 2018 - academic.oup.com
Abstract The PI3K/AKT signaling pathway is an essential node in mammalian cells that
controls cell growth, migration, proliferation, and metabolism. During the last decade, a …
controls cell growth, migration, proliferation, and metabolism. During the last decade, a …
Plasticity of disseminating cancer cells in patients with epithelial malignancies
Current models suggest that at a certain but yet undefined time point of tumour development
malignant cells with an aggressive phenotype start to disseminate via the blood stream into …
malignant cells with an aggressive phenotype start to disseminate via the blood stream into …
Epithelial-mesenchymal plasticity in circulating tumor cells
Abstract Epithelial-to-Mesenchymal Transition (EMT) is a complex process that supports the
migratory capacity of epithelial tumor cells and is thought to play a crucial role in promoting …
migratory capacity of epithelial tumor cells and is thought to play a crucial role in promoting …
New insights into protein kinase B/Akt signaling: role of localized Akt activation and compartment-specific target proteins for the cellular radiation response
Genetic alterations driving aberrant activation of the survival kinase Protein Kinase B (Akt)
are observed with high frequency during malignant transformation and cancer progression …
are observed with high frequency during malignant transformation and cancer progression …
AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteins
M Riggio, MC Perrone, ML Polo, MJ Rodriguez… - Scientific reports, 2017 - nature.com
The purpose of this study was to elucidate the mechanisms associated with the specific
effects of AKT1 and AKT2 isoforms in breast cancer progression. We modulated the …
effects of AKT1 and AKT2 isoforms in breast cancer progression. We modulated the …