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The neutrophil's role during health and disease
Neutrophils have always been considered as uncomplicated front-line troopers of the innate
immune system equipped with limited proinflammatory duties. Yet recently, the role of the …
immune system equipped with limited proinflammatory duties. Yet recently, the role of the …
Neutrophils: New insights and open questions
Neutrophils are the first line of defense against bacteria and fungi and help combat parasites
and viruses. They are necessary for mammalian life, and their failure to recover after …
and viruses. They are necessary for mammalian life, and their failure to recover after …
Neutrophils in acute inflammation: current concepts and translational implications
Modulation of neutrophil recruitment and function is crucial for targeting inflammatory cells to
sites of infection to combat invading pathogens while, at the same time, limiting host tissue …
sites of infection to combat invading pathogens while, at the same time, limiting host tissue …
How leukocytes cross the vascular endothelium
D Vestweber - Nature Reviews Immunology, 2015 - nature.com
Immune responses depend on the ability of leukocytes to move from the circulation into
tissue. This is enabled by mechanisms that guide leukocytes to the right exit sites and allow …
tissue. This is enabled by mechanisms that guide leukocytes to the right exit sites and allow …
[HTML][HTML] Leukocyte migration into inflamed tissues
S Nourshargh, R Alon - Immunity, 2014 - cell.com
Leukocyte migration through activated venular walls is a fundamental immune response that
is prerequisite to the entry of effector cells such as neutrophils, monocytes, and effector T …
is prerequisite to the entry of effector cells such as neutrophils, monocytes, and effector T …
The effects of neutrophil-generated hypochlorous acid and other hypohalous acids on host and pathogens
Neutrophils are predominant immune cells that protect the human body against infections by
deploying sophisticated antimicrobial strategies including phagocytosis of bacteria and …
deploying sophisticated antimicrobial strategies including phagocytosis of bacteria and …
Neutrophil recruitment and function in health and inflammation
Neutrophils have traditionally been thought of as simple foot soldiers of the innate immune
system with a restricted set of pro-inflammatory functions. More recently, it has become …
system with a restricted set of pro-inflammatory functions. More recently, it has become …
Concise review: MSC adhesion cascade—insights into homing and transendothelial migration
Mesenchymal stem cells (MSCs) are promising candidates for adult cell therapies in
regenerative medicine. To fully exert their potential, efficient homing and migration toward …
regenerative medicine. To fully exert their potential, efficient homing and migration toward …
Neutrophils at work
In this Review we discuss data demonstrating recently recognized aspects of neutrophil
homeostasis in the steady state, granulopoiesis in'emergency'conditions and interactions of …
homeostasis in the steady state, granulopoiesis in'emergency'conditions and interactions of …
Selectins: initiators of leucocyte adhesion and signalling at the vascular wall
RP McEver - Cardiovascular research, 2015 - academic.oup.com
The selectins are transmembrane, Ca2+-dependent lectins that mediate leucocyte rolling on
vascular surfaces, the first adhesive step during inflammation and immune surveillance …
vascular surfaces, the first adhesive step during inflammation and immune surveillance …