• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Hypertension is the leading cause of death in human being, which shows high prevalence
and associated complications that increase the mortality and morbidity. Controlling blood …

Document Reviewers: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici
(Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luıs Bronze (Portugal), John …

Importance The benefit of blood pressure lowering for the prevention of dementia or
cognitive impairment is unclear. Objective To determine the association of blood pressure …

High systolic blood pressure (SBP) is a major risk factor for ischemic heart disease (IHD), the
leading cause of death worldwide. Using data from published observational studies and …

As early as the 1920s, and subsequently in the 1959 Build and Blood Pressure Study (S1. 5-
1) of almost 5 million adults insured between 1934 and 1954, a strong direct relationship …

Aims The expression of GADD153 (growth arrest and DNA damage-inducible gene 153), an
apoptosis-regulated gene, increases during endoplasmic reticulum (ER) stress. How …

ACE (angiotensin-converting enzyme) inhibitors and angiotensin receptor blockers (ARBs)
are equally guideline-recommended first-line treatments for hypertension, yet few head-to …

Background—Age-related dementia, most commonly caused by Alzheimer disease or
cerebrovascular factors (vascular dementia), is a major public health threat. Chronic arterial …

Importance High blood pressure (BP) is the most important risk factor for death and
cardiovascular disease (CVD) worldwide. The optimal cutoff for treatment of high BP is …