Islet amyloid polypeptide, islet amyloid, and diabetes mellitus
P Westermark, A Andersson… - Physiological …, 2011 - journals.physiology.org
Islet amyloid polypeptide (IAPP, or amylin) is one of the major secretory products of β-cells of
the pancreatic islets of Langerhans. It is a regulatory peptide with putative function both …
the pancreatic islets of Langerhans. It is a regulatory peptide with putative function both …
Amylin uncovered: a review on the polypeptide responsible for type II diabetes
Amylin is primarily responsible for classifying type II diabetes as an amyloid (protein
misfolding) disease as it has great potential to aggregate into toxic nanoparticles, thereby …
misfolding) disease as it has great potential to aggregate into toxic nanoparticles, thereby …
Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry–mass spectrometry
LM Young, JC Saunders, RA Mahood, CH Revill… - Nature …, 2015 - nature.com
The search for therapeutic agents that bind specifically to precursor protein conformations
and inhibit amyloid assembly is an important challenge. Identifying such inhibitors is difficult …
and inhibit amyloid assembly is an important challenge. Identifying such inhibitors is difficult …
The flavanol (−)-epigallocatechin 3-gallate inhibits amyloid formation by islet amyloid polypeptide, disaggregates amyloid fibrils, and protects cultured cells against …
Islet amyloid polypeptide (IAPP, amylin) is the major protein component of the islet amyloid
deposits associated with type 2 diabetes. The polypeptide lacks a well-defined structure in …
deposits associated with type 2 diabetes. The polypeptide lacks a well-defined structure in …
Ion mobility spectrometry–mass spectrometry defines the oligomeric intermediates in amylin amyloid formation and the mode of action of inhibitors
LM Young, P Cao, DP Raleigh… - Journal of the …, 2014 - ACS Publications
The molecular mechanisms by which different proteins assemble into highly ordered fibrillar
deposits and cause disease remain topics of debate. Human amylin (also known as islet …
deposits and cause disease remain topics of debate. Human amylin (also known as islet …
Islet amyloid polypeptide membrane interactions: effects of membrane composition
Amyloid formation by islet amyloid polypeptide (IAPP) contributes to β-cell dysfunction in
type 2 diabetes. Perturbation of the β-cell membrane may contribute to IAPP-induced …
type 2 diabetes. Perturbation of the β-cell membrane may contribute to IAPP-induced …
The amyloid formation mechanism in human IAPP: dimers have β-strand monomer− monomer interfaces
Early oligomerization of human IAPP (hIAPP) is responsible for β-cell death in the pancreas
and is increasingly considered a primary pathological process linked to Type II Diabetes …
and is increasingly considered a primary pathological process linked to Type II Diabetes …
Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics
Islet amyloidosis by IAPP contributes to pancreatic β-cell death in diabetes, but the nature of
toxic IAPP species remains elusive. Using concurrent time-resolved biophysical and …
toxic IAPP species remains elusive. Using concurrent time-resolved biophysical and …
Ionic strength effects on amyloid formation by amylin are a complicated interplay among Debye screening, ion selectivity, and Hofmeister effects
Amyloid formation plays a role in a wide range of human diseases. The rate and extent of
amyloid formation depend on solution conditions, including pH and ionic strength. Amyloid …
amyloid formation depend on solution conditions, including pH and ionic strength. Amyloid …
Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts
Islet transplantation is a promising treatment for diabetes but long-term success is limited by
progressive graft loss. Aggregates of the beta cell peptide islet amyloid polypeptide (IAPP) …
progressive graft loss. Aggregates of the beta cell peptide islet amyloid polypeptide (IAPP) …