Sphingolipids are highly enriched in the nervous system where they are pivotal constituents
of the plasma membranes and are important for proper brain development and functions …

Sphingolipid metabolism in metazoan cells consists of a complex interconnected web of
numerous enzymes, metabolites and modes of regulation. At the centre of sphingolipid …

In mammals, ceramide, a key intermediate in sphingolipid metabolism and an important
signaling molecule, is synthesized by a family of six ceramide synthases (CerS), each of …

The epidermis and in particular its outermost layer the stratum corneum provides terrestrial
vertebrates with a pivotal defensive barrier against water loss, xenobiotics and harmful …

Ceramide is an important lipid signaling molecule and a key intermediate in sphingolipid
biosynthesis. Recent studies have implied a previously unappreciated role for the ceramide …

The sphingomyelin pathway, which is initiated by sphingomyelin hydrolysis to generate the
second messenger ceramide, signals apoptosis for tumor necrosis factor a, Fas, and …

Ceramide is the key intermediate in the pathway of sphingolipid (SL) 2 biosynthesis (1) and
an important intracellular signaling molecule (2, 3). Ceramide consists of a sphingoid long …

The Lass (longevity-assurance homologue) family members, which are highly conserved
among eukaryotes, function in ceramide synthesis. In the mouse, there are at least five Lass …

Ceramide (N-acylsphingosine) biosynthesis has been proposed to involve introduction of
the 4, 5-trans-double bond of sphingosine after synthesis of dihydroceramide (ie N …

Ceramide is an important lipid signaling molecule that plays critical roles in regulating cell
behavior. Ceramide synthesis is surprisingly complex and is orchestrated by six mammalian …