Tumor microenvironment promotes breast cancer chemoresistance

U Mehraj, AH Dar, NA Wani, MA Mir - Cancer chemotherapy and …, 2021 - Springer
Breast cancer is presently the most predominant tumor type and the second leading cause
of tumor-related deaths among women. Although advancements in diagnosis and …

Evaluating the polarization of tumor-associated macrophages into M1 and M2 phenotypes in human cancer tissue: technicalities and challenges in routine clinical …

SD Jayasingam, M Citartan, TH Thang… - Frontiers in …, 2020 - frontiersin.org
Tumor-associated macrophages (TAMs) as immune cells within the tumor microenvironment
have gained much interests as basic science regarding their roles in tumor progression …

Immune infiltrates in breast cancer: recent updates and clinical implications

MV Dieci, F Miglietta, V Guarneri - Cells, 2021 - mdpi.com
In recent decades, the increasing interest in the field of immunotherapy has fostered an
intense investigation of the breast cancer (BC) immune microenvironment. In this context …

Decoding leader cells in collective cancer invasion

SA Vilchez Mercedes, F Bocci, H Levine… - Nature Reviews …, 2021 - nature.com
Collective cancer invasion with leader–follower organization is increasingly recognized as a
predominant mechanism in the metastatic cascade. Leader cells support cancer invasion by …

[HTML][HTML] Tumor-associated macrophages in breast cancer: Innocent bystander or important player?

SQ Qiu, SJH Waaijer, MC Zwager, EGE de Vries… - Cancer treatment …, 2018 - Elsevier
Tumor-associated macrophages (TAMs) are important tumor-promoting cells in the breast
tumor microenvironment. Preclinically TAMs stimulate breast tumor progression, including …

Single-cell transcriptomic atlas of primate ovarian aging

S Wang, Y Zheng, J Li, Y Yu, W Zhang, M Song, Z Liu… - Cell, 2020 - cell.com
Molecular mechanisms of ovarian aging and female age-related fertility decline remain
unclear. We surveyed the single-cell transcriptomic landscape of ovaries from young and …

Tumor associated macrophages: origin, recruitment, phenotypic diversity, and targeting

T Hourani, JA Holden, W Li, JC Lenzo… - Frontiers in …, 2021 - frontiersin.org
The tumor microenvironment (TME) is known to have a strong influence on tumorigenesis,
with various components being involved in tumor suppression and tumor growth. A …

Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers

F Zhang, NN Parayath, CI Ene, SB Stephan… - Nature …, 2019 - nature.com
Tumor-associated macrophages (TAMs) usually express an M2 phenotype, which enables
them to perform immunosuppressive and tumor-promoting functions. Reprogramming these …

[HTML][HTML] Prognostic significance of tumor-associated macrophages in breast cancer: a meta-analysis of the literature

X Zhao, J Qu, Y Sun, J Wang, X Liu, F Wang, H Zhang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Prognostic significance of tumor-associated macrophages in breast cancer: a meta-analysis of
the literature - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …

Gpr132 sensing of lactate mediates tumor–macrophage interplay to promote breast cancer metastasis

P Chen, H Zuo, H **ong, MJ Kolar… - Proceedings of the …, 2017 - National Acad Sciences
Macrophages are prominent immune cells in the tumor microenvironment that exert potent
effects on cancer metastasis. However, the signals and receivers for the tumor–macrophage …