Indole Alkaloids from Catharanthus roseus: Bioproduction and Their Effect on Human Health

L Almagro, F Fernández-Pérez, MA Pedreño - Molecules, 2015 - mdpi.com
Catharanthus roseus is a medicinal plant belonging to the family Apocynaceae which
produces terpenoid indole alkaloids (TIAs) of high medicinal importance. Indeed, a number …

Secondary metabolites responses of plants exposed to ozone: An update

AA Singh, A Ghosh, M Agrawal, SB Agrawal - Environmental Science and …, 2023 - Springer
Tropospheric ozone (O3) is a secondary pollutant that causes oxidative stress in plants due
to the generation of excess reactive oxygen species (ROS). Phenylpropanoid metabolism is …

Single-cell multi-omics in the medicinal plant Catharanthus roseus

C Li, JC Wood, AH Vu, JP Hamilton… - Nature Chemical …, 2023 - nature.com
Advances in omics technologies now permit the generation of highly contiguous genome
assemblies, detection of transcripts and metabolites at the level of single cells and high …

The seco-iridoid pathway from Catharanthus roseus

K Miettinen, L Dong, N Navrot, T Schneider… - Nature …, 2014 - nature.com
The (seco) iridoids and their derivatives, the monoterpenoid indole alkaloids (MIAs), form
two large families of plant-derived bioactive compounds with a wide spectrum of high-value …

An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis

F Geu-Flores, NH Sherden, V Courdavault, V Burlat… - Nature, 2012 - nature.com
The iridoids comprise a large family of distinctive bicyclic monoterpenes that possess a wide
range of pharmacological activities, including anticancer, anti-inflammatory, antifungal and …

Exploring uncharted territories of plant specialized metabolism in the postgenomic era

JR Jacobowitz, JK Weng - Annual review of plant biology, 2020 - annualreviews.org
For millennia, humans have used plants for food, raw materials, and medicines, but only
within the past two centuries have we begun to connect particular plant metabolites with …

Monoterpenoid indole alkaloids biosynthesis and its regulation in Catharanthus roseus: a literature review from genes to metabolites

Q Pan, NR Mustafa, K Tang, YH Choi… - Phytochemistry reviews, 2016 - Springer
As the only source for the low-abundance antitumor agents vinblastine and vincristine,
Catharanthus roseus is highly valued and has been studied extensively as a model for …

Engineering of secondary metabolism

SE O'Connor - Annual review of genetics, 2015 - annualreviews.org
Secondary (specialized) metabolites, produced by bacteria, fungi, plants, and other
organisms, exhibit enormous structural variation, and consequently display a wide range of …

[HTML][HTML] Pharmacological significance of Catharanthus roseus in cancer management: A review

S Goswami, A Ali, ME Prasad, P Singh - … Research-Modern Chinese …, 2024 - Elsevier
Introduction Catharanthus roseus, commonly known as Vinca Rosea or Madagascar
periwinkle, is a significant plant species within the Apocynaceae family, known for its diverse …

An engineered combinatorial module of transcription factors boosts production of monoterpenoid indole alkaloids in Catharanthus roseus

F Schweizer, M Colinas, J Pollier… - Metabolic …, 2018 - Elsevier
To fend off microbial pathogens and herbivores, plants have evolved a wide range of
defense strategies such as physical barriers, or the production of anti-digestive proteins or …