Macroautophagy is a lysosomal degradative pathway or recycling process that maintains
cellular homeostasis. This autophagy involves a series of sequential processing events …

Ion channels of the Transient Receptor Potential (TRP) family mediate the influx of
monovalent and/or divalent cations into cells in response to a host of chemical or physical …

Protein-coding genes account for only a small part of the human genome, whereas the vast
majority of transcripts make up the non-coding RNAs including long non-coding RNAs …

Osteoarthritis (OA) is a common, painful disease. Currently OA is incurable, and its etiology
largely unknown, partly due to limited understanding of OA as a whole-joint disease. Here …

Malignant melanoma is a neoplasm of melanocytes, and the microphthalmia‐associated
transcription factor (MITF) is essential for the existence of melanocytes. MITF's relevance for …

Melanoma originates in the epidermis and becomes metastatic after invasion into the
dermis. Prior interactions between melanoma cells and dermis are poorly studied. Here, we …

Melanoma treatment with the BRAF V600E inhibitor vemurafenib provides therapeutic
benefits but the common emergence of drug resistance remains a challenge. We generated …

Psoriasis is a chronic and complex inflammatory skin disease with lesions displaying
dramatically altered mRNA expression profiles. However, much less is known about the …

Abstract Background Circular RNAs (circRNAs), a newly discovered type of endogenous
noncoding RNA, have been proposed to mediate the progression of diverse types of tumors …

The etiology and development of human cancers that remain little understood might be
enlightened by defining tumor suppressor microRNAs (TS-miRNA). In this study, we …