Current interest in amyloid fibrils stems from their involvement in neurodegenerative and
other diseases and from their role as an alternative structural state for many peptides and …

The concept of a prion as an infectious self-propagating protein isoform was initially
proposed to explain certain mammalian diseases. It is now clear that yeast also has …

Many peptides and proteins self-assemble into amyloidfibrils. Examples include mammalian
and fungal prion proteins, polypeptides associated with human amyloid diseases, and …

We present a strategy to solve the high-resolution structure of amyloid fibrils by solid-state
NMR and use it to determine the atomic-resolution structure of the prion domain of the fungal …

SUMMARY A prion is an infectious protein horizontally transmitting a disease or trait without
a required nucleic acid. Yeast and fungal prions are nonchromosomal genes composed of …

We structurally compare, using solid-state NMR, two different polymorphs of α-synuclein
which, as established recently, display contrasting biochemical properties, toxicity, and …

The HET-s protein from the filamentous fungus Podospora anserina is a prion involved in a
cell death reaction termed heterokaryon incompatibility. This reaction is observed at the …

[Het-s] is a prion from the filamentous fungus Podospora anserina and corresponds to a self-
perpetuating amyloid aggregate of the HET-s protein. This prion protein is involved in a …

Solid-state NMR spectroscopy has developed into a useful method for protein structure
determination. In contrast to diffraction methods, NMR spectroscopy does not rely on long …

Infectious proteins or prions are a remarkable class of pathogens, where pathogenicity and
infectious state correspond to conformational transition of a protein fold. The conformational …