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Inhibitors of testosterone biosynthetic and metabolic activation enzymes
L Ye, ZJ Su, RS Ge - Molecules, 2011 - mdpi.com
The Leydig cells of the testis have the capacity to biosynthesize testosterone from
cholesterol. Testosterone and its metabolically activated product dihydrotestosterone are …
cholesterol. Testosterone and its metabolically activated product dihydrotestosterone are …
Steroid biosynthesis in adipose tissue
Tissue-specific expression of steroidogenic enzymes allows the modulation of active steroid
levels in a local manner. Thus, the measurement of local steroid concentrations, rather than …
levels in a local manner. Thus, the measurement of local steroid concentrations, rather than …
Gut microbiome variation modulates the effects of dietary fiber on host metabolism
Background There is general consensus that consumption of dietary fermentable fiber
improves cardiometabolic health, in part by promoting mutualistic microbes and by …
improves cardiometabolic health, in part by promoting mutualistic microbes and by …
Structures of human steroidogenic cytochrome P450 17A1 with substrates
EM Petrunak, NM DeVore, PR Porubsky… - Journal of Biological …, 2014 - jbc.org
The human cytochrome P450 17A1 (CYP17A1) enzyme operates at a key juncture of human
steroidogenesis, controlling the levels of mineralocorticoids influencing blood pressure …
steroidogenesis, controlling the levels of mineralocorticoids influencing blood pressure …
Leydig cell and spermatogenesis
RS Ge, X Li, Y Wang - Molecular Mechanisms in Spermatogenesis, 2021 - Springer
Leydig cells of the testis have the capacity to synthesize androgen (mainly testosterone)
from cholesterol. Adult Leydig cells are the cell type for the synthesis of testosterone, which …
from cholesterol. Adult Leydig cells are the cell type for the synthesis of testosterone, which …
The role of adrenal derived androgens in castration resistant prostate cancer
Castration resistant prostate cancer (CRPC) remains androgen dependant despite castrate
levels of circulating testosterone following androgen deprivation therapy, the first line of …
levels of circulating testosterone following androgen deprivation therapy, the first line of …
Structural insights into aldosterone synthase substrate specificity and targeted inhibition
Aldosterone is a major mineralocorticoid hormone that plays a key role in the regulation of
electrolyte balance and blood pressure. Excess aldosterone levels can arise from …
electrolyte balance and blood pressure. Excess aldosterone levels can arise from …
Aromatase inhibitors as a promising direction for the search for new anticancer drugs
Aromatase is an enzyme that plays a crucial role in the biosynthesis of estrogens, which are
hormones that contribute to the growth of certain types of breast cancer. In particular …
hormones that contribute to the growth of certain types of breast cancer. In particular …
Alleviating the unwanted effects of oxidative stress on Aβ clearance: a review of related concepts and strategies for the development of computational modelling
Abstract Treatment for Alzheimer's disease (AD) can be more effective in the early stages.
Although we do not completely understand the aetiology of the early stages of AD, potential …
Although we do not completely understand the aetiology of the early stages of AD, potential …
Hereditary spastic paraplegia: from genes, cells and networks to novel pathways for drug discovery
Hereditary spastic paraplegia (HSP) is a diverse group of Mendelian genetic disorders
affecting the upper motor neurons, specifically degeneration of their distal axons in the …
affecting the upper motor neurons, specifically degeneration of their distal axons in the …