Decoding Toll-like receptors: Recent insights and perspectives in innate immunity

T Kawai, M Ikegawa, D Ori, S Akira - Immunity, 2024 - cell.com
Toll-like receptors (TLRs) are an evolutionarily conserved family in the innate immune
system and are the first line of host defense against microbial pathogens by recognizing …

Human and murine toll-like receptor-driven disease in systemic lupus erythematosus

S von Hofsten, KA Fenton, HL Pedersen - International Journal of …, 2024 - mdpi.com
The pathogenesis of systemic lupus erythematosus (SLE) is linked to the differential roles of
toll-like receptors (TLRs), particularly TLR7, TLR8, and TLR9. TLR7 overexpression or gene …

Targeting TLR signaling cascades in systemic lupus erythematosus and rheumatoid arthritis: An update

GD Kalliolias, EK Basdra, AG Papavassiliou - Biomedicines, 2024 - mdpi.com
Evidence from animal models and human genetics implicates Toll-like Receptors (TLRs) in
the pathogenesis of Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA) …

[HTML][HTML] The effects of the combination therapy of chemotherapy drugs on the fluctuations of genes involved in the TLR signaling pathway in glioblastoma multiforme …

SE Norollahi, S Yousefzadeh-Chabok, B Yousefi… - Biomedicine & …, 2024 - Elsevier
One of the most lethal and aggressive types of malignancies with a high mortality rate and
poor response to treatment is glioblastoma multiforme (GBM). This means that modernizing …

[PDF][PDF] One year in review Systemic lupus erythematosus: one year in review 2024

D Schilirò, E Silvagni, B Ciribè, F Fattorini… - Clin Exp …, 2024 - clinexprheumatol.org
Systemic lupus erythematosus (SLE) is classically regarded as the landmark of systemic
autoimmune diseases, characterised by protean, multi-systemic manifestations and a highly …

Current Progress in the Science of Novel Adjuvant Nano-Vaccine-Induced Protective Immune Responses

MA Saleemi, Y Zhang, G Zhang - Pathogens, 2024 - mdpi.com
Vaccinations are vital as they protect us from various illness-causing agents. Despite all the
advancements in vaccine-related research, develo** improved and safer vaccines against …

POS1190 points to consider for the diagnosis and management of chronic nonbacterial osteitis (CNO) in adults

E Winter, O Dekkers, CM Andreasen… - Annals of the Rheumatic …, 2024 - Elsevier
Background: Adults with sterile bone inflammation are variably labelled as Synovitis, Acne,
Pustulosis, Hyperostosis, Osteitis (SAPHO)-syndrome, chronic nonbacterial osteomyelitis …

POS0551 PHARMACODYNAMIC EFFECTS AND EXPLORATORY EFFICACY OF AFIMETORAN, A TLR7/8 INHIBITOR, IN PATIENTS WITH CUTANEOUS LUPUS …

F Baribaud, J Saini, S Ignatenko, K Chadwick… - Annals of the Rheumatic …, 2024 - Elsevier
Background: Cutaneous lupus erythematosus (CLE) is a chronic inflammatory skin condition
occurring alone or as a manifestation of systemic lupus erythematosus (SLE). With the lack …

Pharmacodynamic effects and exploratory efficacy of afimetoran, a TLR7/8 inhibitor, in patients with cutaneous lupus erythematosus

J Saini, S Ignatenko, K Chadwick… - SKIN The Journal of …, 2024 - skin.dermsquared.com
Background: Cutaneous lupus erythematosus (CLE) is a chronic inflammatory skin condition
occurring alone or as a manifestation of systemic lupus erythematosus (SLE). There is an …