In mammals, erythropoietin (EPO), produced in the kidney, is essential for bone marrow
erythropoiesis, and hypoxia induction of EPO production provides for the important …

Blood flow in the microcirculation is regulated by physiological oxygen (O2) gradients that
are coupled to vasoconstriction or vasodilation, the domain of nitric oxide (NO) bioactivity …

Although the deleterious vasoconstrictive effects of cell-free, hemoglobin-based blood
substitutes have been appreciated, the systemic effects of chronic hemolysis on nitric oxide …

The synthesis of nitric oxide (NO) in the circulation has been attributed exclusively to the
vascular endothelium. Red blood cells (RBCs) have been demonstrated to carry a …

The therapeutic potential of the tocotrienol group stems from its nutraceutical properties as a
dietary supplement. It is largely considered to be safe when consumed at low doses for …

Erythropoietin (EPO) has been shown to protect neurons from ischemic stroke, but can also
increase thrombotic events and mortality rates in patients with ischemic heart disease. We …

Interactions of nitric oxide (NO) with hemoglobin (Hb) could regulate the uptake and delivery
of oxygen (O2) by subserving the classical physiological responses of hypoxic vasodilation …

Background—Anemia is known to be a prognostic marker for patients with heart failure.
However, little is known about the prognostic value of changes in hemoglobin (Hgb) over …

Abstract Erythropoietin (EPO), a hypoxia-inducible cytokine, is required for survival,
proliferation, and differentiation of erythroid progenitor cells. EPO can also stimulate …

Multi-tissue erythropoietin receptor (EPO-R) expression provides for erythropoietin (EPO)
activity beyond its known regulation of red blood cell production. This review highlights the …