Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid

A Drieu, S Du, SE Storck, J Rustenhoven… - Nature, 2022 - nature.com
Macrophages are important players in the maintenance of tissue homeostasis. Perivascular
and leptomeningeal macrophages reside near the central nervous system (CNS) …

APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints

Z Yin, N Rosenzweig, KL Kleemann, X Zhang… - Nature …, 2023 - nature.com
The APOE4 allele is the strongest genetic risk factor for late-onset Alzheimer's disease (AD).
The contribution of microglial APOE4 to AD pathogenesis is unknown, although APOE has …