Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …

BACKGROUND The microtubule-associated protein tau has been implicated in the
pathogenesis of Alzheimer's disease and a range of other neurodegenerative disorders …

Tau is a protein that associates with microtubules (MTs) and promotes their assembly and
stability. The protein loses its ability to bind MTs in tauopathies, and detached tau can …

Pathological tau aggregates cause cognitive decline in neurodegenerative tauopathies,
including Alzheimer's disease (AD). These aggregates are prevalent within intracellular …

The entorhinal-hippocampal system contains distinct networks subserving declarative
memory. This system is selectively vulnerable to changes of ageing and pathological …

Neurological disorders are the leading cause of disability and the second largest cause of
death worldwide. Despite significant research efforts, neurology remains one of the most …

Alzheimer's disease is characterized by the accumulation of amyloid-β plaques, aggregation
of hyperphosphorylated tau (pTau), and microglia activation. Galectin-3 (Gal3) is a β …

Deposits of the microtubule-associated protein Tau (MAPT) serve as a hallmark of
neurodegenerative diseases known as tauopathies. Numerous studies have demonstrated …

As the world population ages, there will be an increasing need for effective therapies for
aging‐associated neurodegenerative disorders, which remain untreatable. Dementia due to …

Hyperphosphorylation and aggregation of the microtubule binding protein tau is a
neuropathological hallmark of Alzheimer's disease/tauopathies. Tau neurotoxicity provokes …