Synthesizing biomaterials in living organisms

X Zhang, J Wang, Y Zhang, Z Yang, J Gao… - Chemical Society …, 2023 - pubs.rsc.org
Living organisms fabricate biomacromolecules such as DNA, RNA, and proteins by the self-
assembly process. The research on the mechanism of biomacromolecule formation also …

[HTML][HTML] How to improve photodynamic therapy-induced antitumor immunity for cancer treatment?

M Zhang, Y Zhao, H Ma, Y Sun, J Cao - Theranostics, 2022 - ncbi.nlm.nih.gov
Photodynamic therapy (PDT) is a promising method of tumor ablation and function-
preserving oncological intervention, which is minimally invasive, repeatable, and has …

Disulfidptosis classification of hepatocellular carcinoma reveals correlation with clinical prognosis and immune profile

T Wang, K Guo, D Zhang, H Wang, J Yin, H Cui… - International …, 2023 - Elsevier
A new mode of cell death, disulfidptosis, has been discovered. Clinical prognostic
significance of disulfidptosis related pattern in hepatocellular carcinoma (HCC). In this study …

Dual aggregations of a near-infrared aggregation-induced emission luminogen for enhanced imaging of Alzheimer's disease

L Xu, H Gao, W Zhan, Y Deng, X Liu… - Journal of the …, 2023 - ACS Publications
Aggregation-induced emission (AIE) enables “Turn-On” imaging generally through single
aggregation of the AIE luminogen (AIEgen). Dual aggregrations of the AIEgen might further …

Polymerization in living organisms

D Wu, J Lei, Z Zhang, F Huang, M Buljan… - Chemical Society …, 2023 - pubs.rsc.org
Vital biomacromolecules, such as RNA, DNA, polysaccharides and proteins, are
synthesized inside cells via the polymerization of small biomolecules to support and multiply …

Supramolecular Senolytics via Intracellular Oligomerization of Peptides in Response to Elevated Reactive Oxygen Species Levels in Aging Cells

S Kim, JB Chae, D Kim, CW Park, Y Sim… - Journal of the …, 2023 - ACS Publications
Senolytics, which eliminate senescent cells from tissues, represent an emerging therapeutic
strategy for various age-related diseases. Most senolytics target antiapoptotic proteins …

Tyrosinase‐Woven Melanin Nets for Melanoma Therapy through Targeted Mitochondrial Tethering and Enhanced Photothermal Treatment

M Tang, T Duan, Y Lu, J Liu, C Gao… - Advanced …, 2024 - Wiley Online Library
Manipulating intracellular biological processes and organelles has emerged as a pivotal
strategy to influence cellular physiological functions. Mitochondria, recognized as the …

Mitochondria-Targeted Gold Biometallization for Photoacoustically Visualized Photothermal Cancer Therapy

Z Luo, Y Cao, Z Liao, N Gong, P Ma, Z Li, X Lai… - ACS …, 2024 - ACS Publications
Subcellular biomineralization systems with cellular intervention functions have shown great
potential in cancer theranostic applications. However, the lack of subcellular specificity, high …

Synthetic nanoassemblies for regulating organelles: from molecular design to precision therapeutics

Y Guo, P Li, X Guo, C Yao, D Yang - ACS nano, 2024 - ACS Publications
Each organelle referring to a complex multiorder architecture executes respective biological
processes via its distinct spatial organization and internal microenvironment. As the …

Morphological Transformation and In Situ Polymerization of Caspase‐3 Responsive Diacetylene‐Containing Lipidated Peptide Amphiphile for Self‐Amplified …

T Ma, R Chen, N Lv, Y Li, ZR Yang, H Qin, Z Li, H Jiang… - Small, 2022 - Wiley Online Library
In order to artificially regulate cell behaviors, intracellular polymerization as an emerging
chemical technique has attracted much attention. Yet, it is still a challenge to achieve …