Brain changes associated with cognitive and emotional factors in chronic pain: a systematic review

A Malfliet, I Coppieters, P Van Wilgen… - … Journal of Pain, 2017 - Wiley Online Library
An emerging technique in chronic pain research is MRI, which has led to the understanding
that chronic pain patients display brain structure and function alterations. Many of these …

Structural and functional brain abnormalities in chronic low back pain: a systematic review☆

J Kregel, M Meeus, A Malfliet, M Dolphens… - Seminars in arthritis and …, 2015 - Elsevier
Objectives The purpose of this systematic review is to analyze the available literature on
structural and functional brain abnormalities in chronic low back pain (CLBP) using several …

Effective treatment of chronic low back pain in humans reverses abnormal brain anatomy and function

DA Seminowicz, TH Wideman, L Naso… - Journal of …, 2011 - Soc Neuroscience
Chronic pain is associated with reduced brain gray matter and impaired cognitive ability. In
this longitudinal study, we assessed whether neuroanatomical and functional abnormalities …

Central sensitization and altered central pain processing in chronic low back pain: fact or myth?

NA Roussel, J Nijs, M Meeus, V Mylius… - The Clinical journal …, 2013 - journals.lww.com
Objective: The purpose of this narrative review is to analyze the available literature
concerning central sensitization and altered central pain processing in patients with chronic …

Cortical changes in chronic low back pain: current state of the art and implications for clinical practice

BM Wand, L Parkitny, NE O'Connell, H Luomajoki… - Manual therapy, 2011 - Elsevier
There is increasing evidence that chronic pain problems are characterised by alterations in
brain structure and function. Chronic back pain is no exception. There is a growing …

Is neuroplasticity in the central nervous system the missing link to our understanding of chronic musculoskeletal disorders?

R Pelletier, J Higgins, D Bourbonnais - BMC musculoskeletal disorders, 2015 - Springer
Background Musculoskeletal rehabilitative care and research have traditionally been guided
by a structural pathology paradigm and directed their resources towards the structural …

Mechanisms-based classifications of musculoskeletal pain: part 1 of 3: symptoms and signs of central sensitisation in patients with low back (±leg) pain

KM Smart, C Blake, A Staines, M Thacker, C Doody - Manual therapy, 2012 - Elsevier
As a mechanisms-based classification of pain 'central sensitisation pain'(CSP) refers to pain
arising from a dominance of neurophysiological dysfunction within the central nervous …

The somatosensory link in fibromyalgia: functional connectivity of the primary somatosensory cortex is altered by sustained pain and is associated with clinical …

J Kim, ML Loggia, CM Cahalan, RE Harris… - Arthritis & …, 2015 - Wiley Online Library
Objective Fibromyalgia (FM) is a chronic functional pain syndrome characterized by
widespread pain, significant pain catastrophizing, sympathovagal dysfunction, and amplified …

A systematic review of structural and functional MRI studies on pain catastrophizing

A Galambos, E Szabó, Z Nagy, AE Édes… - Journal of Pain …, 2019 - Taylor & Francis
Objectives: Pain catastrophizing is reliably associated with pain reports during experimental
pain in healthy, pain-free subjects and in people with chronic pain. It also correlates with self …

The relationship between structural and functional brain changes and altered emotion and cognition in chronic low back pain brain changes: a systematic review of …

SK Ng, DM Urquhart, PB Fitzgerald… - The Clinical journal …, 2018 - journals.lww.com
Objectives: Chronic low back pain (CLBP) is a major health issue, yet its underlying
mechanisms remain unknown. Studies have demonstrated the importance of emotion and …