Pathological mechanisms and therapeutic strategies for Alzheimer's disease
Alzheimer's disease is a rather complex neurodegenerative disease, which is attributed to a
combination of multiple factors. Among the many pathological pathways, synaptic …
combination of multiple factors. Among the many pathological pathways, synaptic …
Mitochondria as a therapeutic target for common pathologies
Although the development of mitochondrial therapies has largely focused on diseases
caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial …
caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial …
Involvement of lipids in Alzheimer's disease pathology and potential therapies
Lipids constitute the bulk of the dry mass of the brain and have been associated with healthy
function as well as the most common pathological conditions of the brain. Demographic …
function as well as the most common pathological conditions of the brain. Demographic …
Oxidative stress, synaptic dysfunction, and Alzheimer's disease
Alzheimer's disease (AD) is a devastating neurodegenerative disorder without a cure. Most
AD cases are sporadic where age represents the greatest risk factor. Lack of understanding …
AD cases are sporadic where age represents the greatest risk factor. Lack of understanding …
Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies
AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …
aging population worldwide. The enormous challenge which AD possesses to global …
Formation and biological targets of quinones: cytotoxic versus cytoprotective effects
Quinones represent a class of toxicological intermediates, which can create a variety of
hazardous effects in vivo including, acute cytotoxicity, immunotoxicity, and carcinogenesis …
hazardous effects in vivo including, acute cytotoxicity, immunotoxicity, and carcinogenesis …
Protective role of IGF-1 and GLP-1 signaling activation in neurological dysfunctions
Abstract Insulin-like growth factor-1 (IGF-1), a pleiotropic polypeptide, plays an essential role
in CNS development and maturation. Glucagon-like peptide-1 (GLP-1) is an endogenous …
in CNS development and maturation. Glucagon-like peptide-1 (GLP-1) is an endogenous …
Mitochondria-targeted antioxidants, an innovative class of antioxidant compounds for neurodegenerative diseases: perspectives and limitations
Neurodegenerative diseases comprise a wide spectrum of pathologies characterized by
progressive loss of neuronal functions and structures. Despite having different genetic …
progressive loss of neuronal functions and structures. Despite having different genetic …
Metabolic dysregulation contributes to the progression of Alzheimer's disease
X Yan, Y Hu, B Wang, S Wang, X Zhang - Frontiers in neuroscience, 2020 - frontiersin.org
Alzheimer's disease (AD) is an incurable neurodegenerative disease. Numerous studies
have demonstrated a critical role for dysregulated glucose metabolism in its pathogenesis …
have demonstrated a critical role for dysregulated glucose metabolism in its pathogenesis …
[HTML][HTML] Mitochondrial dynamics and transport in Alzheimer's disease
Mitochondrial dysfunction is now recognized as a contributing factor to the early pathology of
multiple human conditions including neurodegenerative diseases. Mitochondria are …
multiple human conditions including neurodegenerative diseases. Mitochondria are …