Chromatin folds into dynamic loops that often span hundreds of kilobases and physically
wire distant loci together for gene regulation. These loops are continuously created …

The landscape of pervasive transcription in eukaryotic genomes has made space for the
identification of thousands of transcripts that are difficult to frame in a specific functional …

The cohesin complex is critical for genome organization and regulation, relying on
specialized co-factors to mediate its diverse functional activities. Here, by analyzing patterns …

Senescence of nondividing neurons remains an immature concept, with especially the
regulatory molecular mechanisms of senescence-like phenotypes and the role of proteins …

Abstract Background Lamina-associated domains (LADs) are large genomic regions that
are positioned at the nuclear lamina. It has remained largely unclear what drives the …

Cancer cells often experience large-scale alterations in genome architecture because of
DNA damage and replication stress. Whether mutations in core regulators of chromosome …

Epithelial-mesenchymal transition (EMT) is a dynamic process enabling polarized epithelial
cells to acquire mesenchymal features implicated in development and carcinoma …

The spatial organization of the eukaryotic genome plays an important role in regulating
transcriptional activity. In the nucleus, chromatin forms loops that assemble into fundamental …

Chromosomes in eukaryotic cells undergo compaction at multiple levels and are folded into
hierarchical structures to fit into the nucleus with limited dimensions. Three-dimensional …

Cohesin rings interact with DNA and modulate the expression of thousands of genes. NIPBL
loads cohesin onto chromosomes, and WAPL takes it off. Haploinsufficiency for NIPBL …