Dietary regulation in health and disease

Q Wu, ZJ Gao, X Yu, P Wang - Signal Transduction and Targeted …, 2022 - nature.com
Nutriments have been deemed to impact all physiopathologic processes. Recent evidences
in molecular medicine and clinical trials have demonstrated that adequate nutrition …

tRNA dysregulation and disease

EA Orellana, E Siegal, RI Gregory - Nature Reviews Genetics, 2022 - nature.com
Abstract tRNAs are key adaptor molecules that decipher the genetic code during translation
of mRNAs in protein synthesis. In contrast to the traditional view of tRNAs as ubiquitously …

Real-time detection of 20 amino acids and discrimination of pathologically relevant peptides with functionalized nanopore

M Zhang, C Tang, Z Wang, S Chen, D Zhang, K Li… - Nature …, 2024 - nature.com
Precise identification and quantification of amino acids is crucial for many biological
applications. Here we report a copper (II)-functionalized Mycobacterium smegmatis porin A …

Metabolic pathway analysis using stable isotopes in patients with cancer

CR Bartman, B Faubert, JD Rabinowitz… - Nature Reviews …, 2023 - nature.com
Metabolic reprogramming is central to malignant transformation and cancer cell growth. How
tumours use nutrients and the relative rates of reprogrammed pathways are areas of intense …

tRNA-derived small RNAs in human cancers: roles, mechanisms, and clinical application

M Zhou, X He, J Zhang, C Mei, B Zhong, C Ou - Molecular cancer, 2024 - Springer
Transfer RNA (tRNA)-derived small RNAs (tsRNAs) are a new type of non-coding RNAs
(ncRNAs) produced by the specific cleavage of precursor or mature tRNAs. tsRNAs are …

Transfer RNAs as dynamic and critical regulators of cancer progression

AM Pinzaru, SF Tavazoie - Nature Reviews Cancer, 2023 - nature.com
Transfer RNAs (tRNAs) have been historically viewed as non-dynamic adaptors that decode
the genetic code into proteins. Recent work has uncovered dynamic regulatory roles for …

Valine aminoacyl-tRNA synthetase promotes therapy resistance in melanoma

N El-Hachem, M Leclercq, M Susaeta Ruiz… - Nature cell …, 2024 - nature.com
Transfer RNA dynamics contribute to cancer development through regulation of codon-
specific messenger RNA translation. Specific aminoacyl-tRNA synthetases can either …

Human HDAC6 senses valine abundancy to regulate DNA damage

J **, T Meng, Y Yu, S Wu, CC Jiao, S Song, YX Li… - Nature, 2024 - nature.com
As an essential branched amino acid, valine is pivotal for protein synthesis, neurological
behaviour, haematopoiesis and leukaemia progression,–. However, the mechanism by …

Protein restriction and branched‐chain amino acid restriction promote geroprotective shifts in metabolism

ME Trautman, NE Richardson, DW Lamming - Aging cell, 2022 - Wiley Online Library
The proportion of humans suffering from age‐related diseases is increasing around the
world, and creative solutions are needed to promote healthy longevity. Recent work has …

Valine improves mitochondrial function and protects against oxidative stress

S Sharma, X Zhang, G Azhar, P Patyal… - Bioscience …, 2024 - academic.oup.com
Among the branched-chain amino acids, leucine and isoleucine have been well studied for
their roles in improving mitochondrial function and reducing oxidative stress. However, role …