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Dietary regulation in health and disease
Nutriments have been deemed to impact all physiopathologic processes. Recent evidences
in molecular medicine and clinical trials have demonstrated that adequate nutrition …
in molecular medicine and clinical trials have demonstrated that adequate nutrition …
tRNA dysregulation and disease
EA Orellana, E Siegal, RI Gregory - Nature Reviews Genetics, 2022 - nature.com
Abstract tRNAs are key adaptor molecules that decipher the genetic code during translation
of mRNAs in protein synthesis. In contrast to the traditional view of tRNAs as ubiquitously …
of mRNAs in protein synthesis. In contrast to the traditional view of tRNAs as ubiquitously …
Real-time detection of 20 amino acids and discrimination of pathologically relevant peptides with functionalized nanopore
Precise identification and quantification of amino acids is crucial for many biological
applications. Here we report a copper (II)-functionalized Mycobacterium smegmatis porin A …
applications. Here we report a copper (II)-functionalized Mycobacterium smegmatis porin A …
Metabolic pathway analysis using stable isotopes in patients with cancer
Metabolic reprogramming is central to malignant transformation and cancer cell growth. How
tumours use nutrients and the relative rates of reprogrammed pathways are areas of intense …
tumours use nutrients and the relative rates of reprogrammed pathways are areas of intense …
tRNA-derived small RNAs in human cancers: roles, mechanisms, and clinical application
M Zhou, X He, J Zhang, C Mei, B Zhong, C Ou - Molecular cancer, 2024 - Springer
Transfer RNA (tRNA)-derived small RNAs (tsRNAs) are a new type of non-coding RNAs
(ncRNAs) produced by the specific cleavage of precursor or mature tRNAs. tsRNAs are …
(ncRNAs) produced by the specific cleavage of precursor or mature tRNAs. tsRNAs are …
Transfer RNAs as dynamic and critical regulators of cancer progression
AM Pinzaru, SF Tavazoie - Nature Reviews Cancer, 2023 - nature.com
Transfer RNAs (tRNAs) have been historically viewed as non-dynamic adaptors that decode
the genetic code into proteins. Recent work has uncovered dynamic regulatory roles for …
the genetic code into proteins. Recent work has uncovered dynamic regulatory roles for …
Valine aminoacyl-tRNA synthetase promotes therapy resistance in melanoma
Transfer RNA dynamics contribute to cancer development through regulation of codon-
specific messenger RNA translation. Specific aminoacyl-tRNA synthetases can either …
specific messenger RNA translation. Specific aminoacyl-tRNA synthetases can either …
Human HDAC6 senses valine abundancy to regulate DNA damage
J **, T Meng, Y Yu, S Wu, CC Jiao, S Song, YX Li… - Nature, 2024 - nature.com
As an essential branched amino acid, valine is pivotal for protein synthesis, neurological
behaviour, haematopoiesis and leukaemia progression,–. However, the mechanism by …
behaviour, haematopoiesis and leukaemia progression,–. However, the mechanism by …
Protein restriction and branched‐chain amino acid restriction promote geroprotective shifts in metabolism
The proportion of humans suffering from age‐related diseases is increasing around the
world, and creative solutions are needed to promote healthy longevity. Recent work has …
world, and creative solutions are needed to promote healthy longevity. Recent work has …
Valine improves mitochondrial function and protects against oxidative stress
Among the branched-chain amino acids, leucine and isoleucine have been well studied for
their roles in improving mitochondrial function and reducing oxidative stress. However, role …
their roles in improving mitochondrial function and reducing oxidative stress. However, role …