The diversity of nodes in a complex network causes each node to have varying significance,
and the important nodes often have a significant impact on the structure and function of the …

Many studies have been carried out for early diagnosis of complex diseases by finding
accurate and robust biomarkers specific to respective diseases. In particular, recent rapid …

Considerable evidence suggests that during the progression of complex diseases, the
deteriorations are not necessarily smooth but are abrupt and may cause a critical transition …

A complex disease generally results not from malfunction of individual molecules but from
dysfunction of the relevant system or network, which dynamically changes with time and …

Complex networks such as the Internet, WWW, transportation networks, power grids,
biological neural networks, and scientific cooperation networks of all kinds provide …

Cardiovascular diseases (CVD) are the leading cause of death worldwide and display
complex phenotypic heterogeneity caused by many convergent processes, including …

The tryptophan–kynurenine (KYN) pathway has long been recognized for its essential role
in generating metabolites that influence various physiological processes. Traditionally, these …

Hepatocellular carcinoma (HCC) is a significant health problem worldwide with poor
prognosis. Drug repositioning represents a profitable strategy to accelerate drug discovery …

Network-based computational biology, with the emphasis on biomolecular interactions and
omics-data integration, has had success in drug development and created new directions …