The solid and liquid states of chromatin
The review begins with a concise description of the principles of phase separation. This is
followed by a comprehensive section on phase separation of chromatin, in which we recount …
followed by a comprehensive section on phase separation of chromatin, in which we recount …
The role of the nucleosome acidic patch in modulating higher order chromatin structure
AA Kalashnikova, ME Porter-Goff… - Journal of the …, 2013 - royalsocietypublishing.org
Higher order folding of chromatin fibre is mediated by interactions of the histone H4 N-
terminal tail domains with neighbouring nucleosomes. Mechanistically, the H4 tails of one …
terminal tail domains with neighbouring nucleosomes. Mechanistically, the H4 tails of one …
Driving forces of the complex formation between highly charged disordered proteins
Highly disordered complexes between oppositely charged intrinsically disordered proteins
present a new paradigm of biomolecular interactions. Here, we investigate the driving forces …
present a new paradigm of biomolecular interactions. Here, we investigate the driving forces …
Release of linker histone from the nucleosome driven by polyelectrolyte competition with a disordered protein
Highly charged intrinsically disordered proteins are essential regulators of chromatin
structure and transcriptional activity. Here we identify a surprising mechanism of molecular …
structure and transcriptional activity. Here we identify a surprising mechanism of molecular …
Protein–polyelectrolyte complexes and micellar assemblies
S Gao, A Holkar, S Srivastava - Polymers, 2019 - mdpi.com
In this review, we highlight the recent progress in our understanding of the structure,
properties and applications of protein–polyelectrolyte complexes in both bulk and micellar …
properties and applications of protein–polyelectrolyte complexes in both bulk and micellar …
Epigenetic regulation in lung cancer
Lung cancer is indeed a major cause of cancer‐related deaths worldwide. The development
of tumors involves a complex interplay of genetic, epigenetic, and environmental factors …
of tumors involves a complex interplay of genetic, epigenetic, and environmental factors …
Non-equilibrium behaviour in coacervate-based protocells under electric-field-induced excitation
Although numerous strategies are now available to generate rudimentary forms of synthetic
cell-like entities, minimal progress has been made in the sustained excitation of artificial …
cell-like entities, minimal progress has been made in the sustained excitation of artificial …
Liquid-liquid phase separation (LLPS) in DNA and chromatin systems from the perspective of colloid physical chemistry
DNA is a highly charged polyelectrolyte and is prone to associative phase separation driven
by the presence of multivalent cations, charged surfactants, proteins, polymers and colloids …
by the presence of multivalent cations, charged surfactants, proteins, polymers and colloids …
Deciphering principles of nucleosome interactions and impact of cancer-associated mutations from comprehensive interaction network analysis
Nucleosomes represent hubs in chromatin organization and gene regulation and interact
with a plethora of chromatin factors through different modes. In addition, alterations in …
with a plethora of chromatin factors through different modes. In addition, alterations in …
The 10-nm chromatin fiber and its relationship to interphase chromosome organization
A chromosome is a single long DNA molecule assembled along its length with nucleosomes
and proteins. During interphase, a mammalian chromosome exists as a highly organized …
and proteins. During interphase, a mammalian chromosome exists as a highly organized …