Exerkines in health, resilience and disease

LS Chow, RE Gerszten, JM Taylor… - Nature Reviews …, 2022 - nature.com
The health benefits of exercise are well-recognized and are observed across multiple organ
systems. These beneficial effects enhance overall resilience, healthspan and longevity. The …

Physical activity and muscle–brain crosstalk

BK Pedersen - Nature Reviews Endocrinology, 2019 - nature.com
Neurological and mental illnesses account for a considerable proportion of the global
burden of disease. Exercise has many beneficial effects on brain health, contributing to …

Adiponectin: Structure, physiological functions, role in diseases, and effects of nutrition

K Khoramipour, K Chamari, AA Hekmatikar, A Ziyaiyan… - Nutrients, 2021 - mdpi.com
Adiponectin (a protein consisting of 244 amino acids and characterized by a molecular
weight of 28 kDa) is a cytokine that is secreted from adipose tissues (adipokine). Available …

The effects of aging in the hippocampus and cognitive decline

LEB Bettio, L Rajendran, J Gil-Mohapel - Neuroscience & Biobehavioral …, 2017 - Elsevier
Aging is a natural process that is associated with cognitive decline as well as functional and
social impairments. One structure of particular interest when considering aging and …

Tryptophan-metabolizing gut microbes regulate adult neurogenesis via the aryl hydrocarbon receptor

GZ Wei, KA Martin, PY **ng… - Proceedings of the …, 2021 - National Acad Sciences
While modulatory effects of gut microbes on neurological phenotypes have been reported,
the mechanisms remain largely unknown. Here, we demonstrate that indole, a tryptophan …

Beneficial effects of exercise on depression and anxiety during the Covid-19 pandemic: a narrative review

S Hu, L Tucker, C Wu, L Yang - Frontiers in psychiatry, 2020 - frontiersin.org
First reported in Dec 2019, the on-going COVID-19 pandemic has become a public health
emergency of international concern (PHEIC). The isolation and quarantine during the …

[HTML][HTML] Depression and adult neurogenesis: Positive effects of the antidepressant fluoxetine and of physical exercise

L Micheli, M Ceccarelli, G D'Andrea, F Tirone - Brain research bulletin, 2018 - Elsevier
Of wide interest for health is the relation existing between depression, a very common
psychological illness, accompanied by anxiety and reduced ability to concentrate, and adult …

Depression in neurodegenerative diseases: Common mechanisms and current treatment options

CPC Galts, LEB Bettio, DC Jewett, CC Yang… - Neuroscience & …, 2019 - Elsevier
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major
cause of disability worldwide. This neurological condition is commonly associated with …

Endocrine crosstalk between skeletal muscle and the brain

J Delezie, C Handschin - Frontiers in neurology, 2018 - frontiersin.org
Skeletal muscle is an essential regulator of energy homeostasis and a potent coordinator of
exercise-induced adaptations in other organs including the liver, fat or the brain. Skeletal …

The role of leptin and adiponectin in obesity-associated cognitive decline and Alzheimer's disease

L Forny-Germano, FG De Felice… - Frontiers in …, 2019 - frontiersin.org
Cross-talk between adipose tissue and central nervous system (CNS) underlies the
increased risk of obese people to develop brain diseases such as cognitive and mood …