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Exerkines in health, resilience and disease
LS Chow, RE Gerszten, JM Taylor… - Nature Reviews …, 2022 - nature.com
The health benefits of exercise are well-recognized and are observed across multiple organ
systems. These beneficial effects enhance overall resilience, healthspan and longevity. The …
systems. These beneficial effects enhance overall resilience, healthspan and longevity. The …
Adiponectin: structure, physiological functions, role in diseases, and effects of nutrition
Adiponectin (a protein consisting of 244 amino acids and characterized by a molecular
weight of 28 kDa) is a cytokine that is secreted from adipose tissues (adipokine). Available …
weight of 28 kDa) is a cytokine that is secreted from adipose tissues (adipokine). Available …
Physical activity and muscle–brain crosstalk
BK Pedersen - Nature Reviews Endocrinology, 2019 - nature.com
Neurological and mental illnesses account for a considerable proportion of the global
burden of disease. Exercise has many beneficial effects on brain health, contributing to …
burden of disease. Exercise has many beneficial effects on brain health, contributing to …
[HTML][HTML] Mitochondrial dysfunction: a fatal blow in depression
Y Song, H Cao, C Zuo, Z Gu, Y Huang, J Miao… - Biomedicine & …, 2023 - Elsevier
Mitochondria maintain the normal physiological function of nerve cells by producing
sufficient cellular energy and performing crucial roles in maintaining the metabolic balance …
sufficient cellular energy and performing crucial roles in maintaining the metabolic balance …
The effects of aging in the hippocampus and cognitive decline
Aging is a natural process that is associated with cognitive decline as well as functional and
social impairments. One structure of particular interest when considering aging and …
social impairments. One structure of particular interest when considering aging and …
Tryptophan-metabolizing gut microbes regulate adult neurogenesis via the aryl hydrocarbon receptor
GZ Wei, KA Martin, PY **ng, R Agrawal… - Proceedings of the …, 2021 - pnas.org
While modulatory effects of gut microbes on neurological phenotypes have been reported,
the mechanisms remain largely unknown. Here, we demonstrate that indole, a tryptophan …
the mechanisms remain largely unknown. Here, we demonstrate that indole, a tryptophan …
Depression in neurodegenerative diseases: Common mechanisms and current treatment options
CPC Galts, LEB Bettio, DC Jewett, CC Yang… - Neuroscience & …, 2019 - Elsevier
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major
cause of disability worldwide. This neurological condition is commonly associated with …
cause of disability worldwide. This neurological condition is commonly associated with …
[HTML][HTML] Depression and adult neurogenesis: Positive effects of the antidepressant fluoxetine and of physical exercise
Of wide interest for health is the relation existing between depression, a very common
psychological illness, accompanied by anxiety and reduced ability to concentrate, and adult …
psychological illness, accompanied by anxiety and reduced ability to concentrate, and adult …
Endocrine crosstalk between skeletal muscle and the brain
Skeletal muscle is an essential regulator of energy homeostasis and a potent coordinator of
exercise-induced adaptations in other organs including the liver, fat or the brain. Skeletal …
exercise-induced adaptations in other organs including the liver, fat or the brain. Skeletal …
Beneficial effects of exercise on depression and anxiety during the Covid-19 pandemic: a narrative review
S Hu, L Tucker, C Wu, L Yang - Frontiers in psychiatry, 2020 - frontiersin.org
First reported in Dec 2019, the on-going COVID-19 pandemic has become a public health
emergency of international concern (PHEIC). The isolation and quarantine during the …
emergency of international concern (PHEIC). The isolation and quarantine during the …