BackgroundSubjects at ultra high-risk (UHR) for psychosis have an enhanced vulnerability
to develop the disorder but the risk factors accounting for this accrued risk are undetermined …

Context During the past 2 decades, a major transition in the clinical characterization of
psychotic disorders has occurred. The construct of a clinical high-risk (HR) state for …

Importance Detection, prognosis, and indicated interventions in individuals at clinical high
risk for psychosis (CHR-P) are key components of preventive psychiatry. Objective To …

Importance Individuals can be classified as being at clinical high risk (CHR) for psychosis if
they meet at least one of the ultra–high-risk (UHR) inclusion criteria (brief limited intermittent …

Objective: The purpose of this study was to determine whether microglial activity, measured
using translocator-protein positron emission tomography (PET) imaging, is increased in …

Background: The current diagnostic system for subjects at enhanced clinical risk of
psychosis allows concurrent comorbid diagnoses of anxiety and depressive disorders. Their …

Importance The overall effect of At Risk Mental State (ARMS) services for the detection of
individuals who will develop psychosis in secondary mental health care is undetermined …

Despite historical assumptions to the contrary, there is little evidence that the majority of
recognized mental disorders are separated by natural boundaries. Diagnostic categories …

Objective: Two-thirds of individuals identified as at ultra-high risk for psychosis do not
develop psychotic disorder over the medium term. The authors examined outcomes in a …

Decades of research have examined the effects of cannabis on neurocognition. Recent
advances in this field provide us with a better understanding of how cannabis use influences …