Glioblastoma multiforme (GBM) is a WHO grade IV glioma and the most common malignant,
primary brain tumor with a 5-year survival of 7.2%. Its highly infiltrative nature, genetic …

The systemic spread of tumor cells is the ultimate cause of the majority of deaths from
cancer, yet few successful therapeutic strategies have emerged to specifically target …

There is a lot of evidence showing that lipid peroxidation plays very important role in
development of various diseases, including neurodegenerative diseases and brain tumors …

Temozolomide (TMZ) is the first-line chemotherapy drug that has been used to treat glioma
for over a decade, but the benefits are limited by half of the treated patients who acquired …

This sco** review examines the use of CRISPR/Cas9 gene editing in glioblastoma (GBM),
a predominant and aggressive brain tumor. Categorizing gene targets into distinct groups …

Ferroptosis, characterized by iron-dependent lipid reactive oxygen species (ROS)
accumulation, is non-apoptotic programmed cell death highly relevant to tumor …

Glioblastoma stem cells (GSCs) are cells with a self-renewal ability and capacity to initiate
tumors upon serial transplantation that have been linked to tumor cell heterogeneity. Most …

Significance: Redox pioneer Helmut Sies attempted to explain reactive species' challenges
faced by organelles, cells, tissues, and organs via three complementary definitions:(i) …

Glioblastoma (GBM) is the most common malignant craniocerebral tumor. The treatment of
this cancer is difficult due to its high heterogeneity and immunosuppressive …

Although there is no doubt regarding the involvement of oxidative stress in the development
of glioblastoma, many questions remained unanswered about signaling cascades that …