Cotinine: pharmacologically active metabolite of nicotine and neural mechanisms for its actions
X Tan, K Vrana, ZM Ding - Frontiers in Behavioral Neuroscience, 2021 - frontiersin.org
Tobacco use disorder continues to be a leading public health issue and cause of premature
death in the United States. Nicotine is considered as the major tobacco alkaloid causing …
death in the United States. Nicotine is considered as the major tobacco alkaloid causing …
Vascular depression consensus report–a critical update
Background Vascular depression is regarded as a subtype of late-life depression
characterized by a distinct clinical presentation and an association with cerebrovascular …
characterized by a distinct clinical presentation and an association with cerebrovascular …
Nicotinic acetylcholine receptors and learning and memory deficits in Neuroinflammatory diseases
Animal survival depends on cognitive abilities such as learning and memory to adapt to
environmental changes. Memory functions require an enhanced activity and connectivity of …
environmental changes. Memory functions require an enhanced activity and connectivity of …
Strategies for the treatment of Parkinson's disease: beyond dopamine
Parkinson's disease (PD) is the second-leading cause of dementia and is characterized by a
progressive loss of dopaminergic neurons in the substantia nigra alongside the presence of …
progressive loss of dopaminergic neurons in the substantia nigra alongside the presence of …
Is VEGF a key target of cotinine and other potential therapies against Alzheimer disease?
Background: The vascular endothelial growth factor (VEGF) is a neuroprotective cytokine
that promotes neurogenesis and angiogenesis in the brain. In animal models, it has been …
that promotes neurogenesis and angiogenesis in the brain. In animal models, it has been …
A new outlook on cholinergic interneurons in Parkinson's disease and L-DOPA-induced dyskinesia
Traditionally, dopamine (DA) and acetylcholine (ACh) striatal systems were considered
antagonistic and imbalances or aberrant signaling between these neurotransmitter systems …
antagonistic and imbalances or aberrant signaling between these neurotransmitter systems …
Ultrasound of alternating frequencies and variable emotional impact evokes depressive syndrome in mice and rats
A Morozova, E Zubkov, T Strekalova… - Progress in Neuro …, 2016 - Elsevier
Emotional stress is primarily triggered by the cognitive processing of negative input; it is
regarded as a serious pathogenetic factor of depression that is challenging to model in …
regarded as a serious pathogenetic factor of depression that is challenging to model in …
Nicotinic ligands as multifunctional agents for the treatment of neuropsychiatric disorders
AV Terry Jr, PM Callahan, CM Hernandez - Biochemical pharmacology, 2015 - Elsevier
The challenges associated with develo** more effective treatments for neurologic and
psychiatric illness such as Alzheimer's disease and schizophrenia are considerable. Both …
psychiatric illness such as Alzheimer's disease and schizophrenia are considerable. Both …
Molecular insights into memory-enhancing metabolites of nicotine in brain: a systematic review
Background: The alleged procognitive effects of nicotine and its metabolites in brain are
controversial. Objective: Here, we review the pharmacologically active metabolites of …
controversial. Objective: Here, we review the pharmacologically active metabolites of …
Post-treatment with cotinine improved memory and decreased depressive-like behavior after chemotherapy in rats
Purpose Most cancer patients treated with systemic adjuvant chemotherapy endure long-
lasting side effects including decrease in concentration, forgetfulness and slower thinking …
lasting side effects including decrease in concentration, forgetfulness and slower thinking …